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Tbio
AQP12A
Aquaporin-12A

Protein Summary
Description
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337801
  • ENSP00000337144
  • ENSG00000184945

Symbol
  • AQP12
  • AQPX2
  • AQP12
  • AQPX2
  • AQP-12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cell type or tissue
0.56
disease
0.43
chemical
0.41
cell line
0.35


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.34   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.34   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
MIP
Tbio
Novelty:  0.00299543
Score:  0.916
Data Source:  STRINGDB
AQP8
Tbio
Novelty:  0.00613662
Score:  0.903
Data Source:  STRINGDB
AQP10
Tbio
Novelty:  0.03507619
Score:  0.886
Data Source:  STRINGDB
AQP3
Tchem
Novelty:  0.00177269
Score:  0.87
Data Source:  STRINGDB
AQP6
Tbio
Novelty:  0.02315464
Score:  0.867
Data Source:  STRINGDB
AQP7
Tbio
Novelty:  0.0044814
Score:  0.865
Data Source:  STRINGDB
AQP4
Tbio
Novelty:  0.00031632
Score:  0.862
Data Source:  STRINGDB
AQP5
Tbio
Novelty:  0.00198806
Score:  0.846
Data Source:  STRINGDB
AQP1
Tbio
Novelty:  0.00067935
Score:  0.839
Data Source:  STRINGDB
AQP2
Tbio
Novelty:  0.00088471
Score:  0.831
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Passive transport by Aquaporins
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Passive transport by Aquaporins
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
82.6
monocyte count
2
1
2
82
monocyte percentage of leukocytes
1
1
1
80.7
1
1
0
1.1
73.7
1
1
0
1.4
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
82.6
monocyte count
2
82
monocyte percentage of leukocytes
1
80.7
0
1.1
73.7
0
1.4
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2664636
208760
Rat
RGD:1562727
367316
Anole lizard
aquaporin-12
100561817
Zebrafish
ZDB-GENE-040718-310
436844
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Anole lizard
aquaporin-12
Zebrafish
Publication Statistics
PubMed Score 17.34
PubMed score by year
PubTator Score 8.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title