AQP1
Aquaporin-1
Protein Summary
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement. [provided by RefSeq, Aug 2016]
- ENST00000311813
- ENSP00000311165
- ENSG00000240583
- ENST00000409611
- ENSP00000387178
- ENST00000409899
- ENSP00000386712
- ENST00000441328
- ENSP00000405698
- CHIP28
- CO
- CHIP28
- AQP-CHIP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
gene perturbation | 0.85 | ||
small molecule perturbation | 0.78 | ||
disease | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1762.24 (req: < 5)
Gene RIFs: 244 (req: <= 3)
Antibodies: 510 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1762.24 (req: >= 5)
Gene RIFs: 244 (req: > 3)
Antibodies: 510 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 52
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0