Tbio APPL1 DCC-interacting protein 13-alpha

Protein Summary

Description

Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway. The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UKG1
• Q9P2B9
• Dip13-alpha

Gene Name

• APPL1

Ensembl ID

• ENST00000288266
• ENSP00000288266
• ENSG00000157500
• ENST00000650354
• ENSP00000498115

Symbol

• APPL
• DIP13A
• KIAA1428
• APPL
• MODY14
• DIP13alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.91
transcription factor perturbation	0.8
histone modification site profile	0.79
hub protein	0.75
tissue sample	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.81   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 337   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.81   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (189)

Explore Interacting Targets

1 – 10 of 189

• See Interactions on String-DB

APPL2

Tbio

Novelty:  0.18610793

p_int:  1

Score:  0.531

Data Source:  BioPlex,STRINGDB

ZNF830

Tdark

Novelty:  0.38957008

p_int:  0.998266313

p_ni:  0.001567216

p_wrong:  0.000166471

Score:  0.197

Data Source:  BioPlex,STRINGDB

C16orf70

Tdark

Novelty:  2.12573065

p_int:  0.998233981

p_ni:  0.001766019

Score:  0.207

Data Source:  BioPlex,STRINGDB

TPCN2

Tchem

Family:  IC

Novelty:  0.01351129

p_int:  0.947910813

p_ni:  0.052089187

Score:  0.258

Data Source:  BioPlex,STRINGDB

FAM167A

Tbio

Novelty:  0.05232679

p_int:  0.890448197

p_ni:  0.109551803

Data Source:  BioPlex

KLHL2

Tbio

Novelty:  0.07279226

p_int:  0.849543219

p_ni:  0.150456781

Score:  0.173

Data Source:  BioPlex,STRINGDB

GIPC2

Tbio

Novelty:  0.21044026

p_int:  0.844490038

p_ni:  0.155509962

Score:  0.496

Data Source:  BioPlex,STRINGDB

AKT1

Tchem

Family:  Kinase

Novelty:  0.00003185

Score:  0.987

Data Source:  STRINGDB

ADIPOR1

Tbio

Novelty:  0.00273623

Score:  0.982

Data Source:  STRINGDB

ADIPOR2

Tbio

Novelty:  0.00330423

Score:  0.978

Data Source:  STRINGDB

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (3)

1 – 3 of 3

PIK3CA

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  3

1: Longevity regulating pathway

2: Pathways in cancer

3: Colorectal cancer

PIK3CD

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  3

1: Longevity regulating pathway

2: Pathways in cancer

3: Colorectal cancer

BCL2

Tclin

Family:  Other

KEGG Distance:  3

Common Pathways:  2

1: Pathways in cancer

2: Colorectal cancer

Pathways (15)

Reactome (4)

KEGG (3)

PathwayCommons (4)

WikiPathways (4)

Apoptosis (R-HSA-109581)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Caspase activation via Dependence Receptors in the absence of ligand	10 targets	R-HSA-418889
Reactome	Caspase activation via extrinsic apoptotic signalling pathway	26 targets	R-HSA-5357769
Reactome	Programmed Cell Death	180 targets	R-HSA-5357801

Name	Explore in Pharos	Explore in Source
Apoptosis	177 targets	R-HSA-109581
Caspase activation via Dependence Receptors in the absence of ligand	10 targets	R-HSA-418889
Caspase activation via extrinsic apoptotic signalling pathway	26 targets	R-HSA-5357769
Programmed Cell Death	180 targets	R-HSA-5357801

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (3)

Components (7)

Processes (8)

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1 – 3 of 3

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protein kinase B binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protein-containing complex binding	Inferred from Physical Interaction (IPI)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
IGF-1 measurement	EFO_0004627	1	1	1		5.5
Alzheimer's disease	EFO_0000249	1	1	0	5.7	3.2
family history of Alzheimer’s disease	EFO_0009268	1	1	0	5.7	3.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
IGF-1 measurement	EFO_0004627	1		5.5
Alzheimer's disease	EFO_0000249	0	5.7	3.2
family history of Alzheimer’s disease	EFO_0009268	0	5.7	3.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell cycle
Coiled coil
Complete proteome
Diabetes mellitus
Disease mutation
Endosome
Membrane
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
Alzheimer's disease
family history of Alzheimer’s disease
IGF-1 measurement

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
muscle phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	VGNC:8730	460469
Mouse	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	MGI:1920243	72993
Rat	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	RGD:1309388	290537
Dog	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	VGNC:38012	484716
Horse	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	VGNC:15430	100058653

Species	Name	OMA	EggNOG	Inparanoid
Chimp	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Mouse	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Rat	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Dog	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Horse	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

Publication Statistics

PubMed Score 125.81

PubMed score by year

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PubTator Score 89.11

PubTator score by year

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Related Publications

Text Mined References (79)

GeneRif Annotations (53)

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PMID	Year	Title