APPL1
DCC-interacting protein 13-alpha
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
microRNA | 0.91 | ||
transcription factor perturbation | 0.8 | ||
histone modification site profile | 0.79 | ||
hub protein | 0.75 | ||
tissue sample | 0.72 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Caspase activation via Dependence Receptors in the absence of ligand | ||||
Reactome | Caspase activation via extrinsic apoptotic signalling pathway | ||||
Reactome | Programmed Cell Death | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Apoptosis | ||||
Caspase activation via Dependence Receptors in the absence of ligand | ||||
Caspase activation via extrinsic apoptotic signalling pathway | ||||
Programmed Cell Death | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
IGF-1 measurement | 1 | 1 | 1 | 5.5 | |||||
1 | 1 | 0 | 5.7 | 3.2 | |||||
family history of Alzheimer’s disease | 1 | 1 | 0 | 5.7 | 3.2 | ||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
IGF-1 measurement | 1 | 5.5 | |||||
0 | 5.7 | 3.2 | |||||
family history of Alzheimer’s disease | 0 | 5.7 | 3.2 | ||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | VGNC:8730 | 460469 | |||||
Mouse | MGI:1920243 | 72993 | ||||||
Rat | RGD:1309388 | 290537 | ||||||
Dog | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | VGNC:38012 | 484716 | |||||
Horse | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | VGNC:15430 | 100058653 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | |||||
Horse | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | |||||
PMID | Year | Title |
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