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Tbio
APPBP2
Amyloid protein-binding protein 2

Protein Summary
Description
May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000083182
  • ENSP00000083182
  • ENSG00000062725

Symbol
  • KIAA0228
  • PAT1
  • PAT1
  • APP-BP2
  • HS.84084
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.91
hub protein
0.79
transcription factor binding site profile
0.73
cell line
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.44   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.44   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.999997276
p_ni:  0.000002724
Score:  0.53
Data Source:  BioPlex,STRINGDB
COPS8
Tbio
Novelty:  0.0408885
p_int:  0.999974702
p_ni:  0.000025166
p_wrong:  1.31e-7
Score:  0.51
Data Source:  BioPlex,STRINGDB
CUL2
Tbio
Novelty:  0.00512916
p_int:  0.999969541
p_ni:  0.000030459
Score:  0.242
Data Source:  BioPlex,STRINGDB
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.999939066
p_ni:  0.000060876
p_wrong:  5.8e-8
Data Source:  BioPlex
COPS7B
Tbio
Novelty:  0.63421506
p_int:  0.999812419
p_ni:  0.000187581
Score:  0.216
Data Source:  BioPlex,STRINGDB
DOCK8
Tbio
Novelty:  0.0067047
p_int:  0.999258425
p_ni:  0.000741575
Data Source:  BioPlex
C1QTNF2
Tbio
Novelty:  0.18607978
p_int:  0.999221892
p_ni:  0.000777837
p_wrong:  2.71e-7
Data Source:  BioPlex
XRCC4
Tbio
Novelty:  0.00305644
p_int:  0.99920304
p_ni:  0.00079696
Score:  0.205
Data Source:  BioPlex,STRINGDB
INTU
Tbio
Novelty:  0.02714388
p_int:  0.998568328
p_ni:  0.001431669
p_wrong:  3e-9
Data Source:  BioPlex
COPS3
Tbio
Novelty:  0.04664225
p_int:  0.993481028
p_ni:  0.00651721
p_wrong:  0.000001762
Score:  0.542
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
75
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
75
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amyloid beta precursor protein binding protein 2
VGNC:9141
454804
Macaque
amyloid beta precursor protein binding protein 2
716680
Mouse
MGI:1914134
66884
Rat
RGD:1306488
303396
Dog
amyloid beta precursor protein binding protein 2
VGNC:38011
480588
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amyloid beta precursor protein binding protein 2
Macaque
amyloid beta precursor protein binding protein 2
Mouse
Rat
Dog
amyloid beta precursor protein binding protein 2
Publication Statistics
PubMed Score 5.44
PubMed score by year
PubTator Score 29.43
PubTator score by year
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Related Publications
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PMID
Year
Title