Tbio APOM Apolipoprotein M

Protein Summary

Description

Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid. The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• O95445
• B0UX98
• Q5SRP4
• Q9P046
• Q9UMP6
• Apo-M

Gene Name

• APOM

Ensembl ID

• ENST00000375916
• ENSP00000365081
• ENSG00000204444
• ENST00000375920
• ENSP00000365085
• ENST00000383438
• ENSP00000372930
• ENSG00000206409
• ENST00000400157
• ENSP00000383021
• ENST00000416324
• ENSP00000393581
• ENSG00000224290
• ENST00000422771
• ENSP00000392021
• ENSG00000226215
• ENST00000425177
• ENSP00000403062
• ENSG00000235754
• ENST00000426800
• ENSP00000405730
• ENSG00000227567
• ENST00000430282
• ENSP00000401684
• ENST00000432598
• ENSP00000389591
• ENST00000436931
• ENSP00000394610
• ENSG00000231974
• ENST00000439902
• ENSP00000413446
• ENST00000441436
• ENSP00000398944
• ENST00000443975
• ENSP00000416335

Symbol

• G3A
• NG20
• G3a
• NG20
• apo-M
• HSPC336

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
histone modification site profile	0.76
cellular component	0.73
disease	0.71
transcription factor perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.8   (req: < 5)

Gene RIFs: 115   (req: <= 3)

Antibodies: 486   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.8   (req: >= 5)

Gene RIFs: 115   (req: > 3)

Antibodies: 486   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0