Protein Summary
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000249066
- ENSP00000249066
- ENSG00000128335
- ENST00000358502
- ENSP00000351292
- APOL3
- APOL-II
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.95 | ||
gene perturbation | 0.93 | ||
PubMedID | 0.61 | ||
microRNA | 0.55 | ||
transcription factor | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 181 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 181 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (37)
APBB2
Novelty: 0.06546724
p_int: 0.990286894
p_ni: 0.009713067
p_wrong: 3.9e-8
Data Source: BioPlex
BPNT1
Family: Enzyme
Novelty: 0.1114547
p_int: 0.987165522
p_ni: 0.012834478
Data Source: BioPlex
DPP6
Family: Enzyme
Novelty: 0.00435138
p_int: 0.983802268
p_ni: 0.01583508
p_wrong: 0.000362652
Data Source: BioPlex
PSG9
Novelty: 0.0426075
p_int: 0.979154799
p_ni: 0.020842407
p_wrong: 0.000002794
Score: 0.202
Data Source: BioPlex,STRINGDB
CHRNB1
Family: IC
Novelty: 0.04777051
p_int: 0.971266525
p_ni: 0.026659161
p_wrong: 0.002074314
Data Source: BioPlex
ERAP1
Family: Enzyme
Novelty: 0.00404539
p_int: 0.966760407
p_ni: 0.03323856
p_wrong: 0.000001033
Score: 0.199
Data Source: BioPlex,STRINGDB
CHRND
Family: IC
Novelty: 0.0441685
p_int: 0.959039527
p_ni: 0.040959241
p_wrong: 0.000001233
Data Source: BioPlex
CHRNA3
Family: IC
Novelty: 0.00659767
p_int: 0.955776898
p_ni: 0.044223099
p_wrong: 3e-9
Score: 0.222
Data Source: BioPlex,STRINGDB
GBP5
Novelty: 0.03705719
p_int: 0.934902466
p_ni: 0.062035741
p_wrong: 0.003061793
Score: 0.259
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (3)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum alanine aminotransferase measurement | 3 | 3 | 2 | 12.2 | 94.3 | ||||
alkaline phosphatase measurement | 2 | 2 | 1 | 7.8 | 88.6 | ||||
aspartate aminotransferase measurement | 2 | 2 | 1 | 7.5 | 87.4 | ||||
heel bone mineral density | 2 | 2 | 2 | 79.5 | |||||
2 | 2 | 0 | 2.2 | 74.1 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum alanine aminotransferase measurement | 2 | 12.2 | 94.3 | ||||
alkaline phosphatase measurement | 1 | 7.8 | 88.6 | ||||
aspartate aminotransferase measurement | 1 | 7.5 | 87.4 | ||||
heel bone mineral density | 2 | 79.5 | |||||
0 | 2.2 | 74.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | apolipoprotein L2 | VGNC:6687 | 741411 | |||||
Macaque | apolipoprotein L2 | 694029 | ||||||
Mouse | MGI:1923011 | 75761 | ||||||
Rat | RGD:6490440 | 100911804 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | apolipoprotein L2 | |||||
Macaque | apolipoprotein L2 | |||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 15.00
PubMed score by year
PubTator Score 6.41
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
|---|