You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
APOL2
Apolipoprotein L2

Protein Summary
Description
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249066
  • ENSP00000249066
  • ENSG00000128335
  • ENST00000358502
  • ENSP00000351292

Symbol
  • APOL3
  • APOL-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
gene perturbation
0.93
PubMedID
0.61
microRNA
0.55
transcription factor
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
APBB2
Tbio
Novelty:  0.06546724
p_int:  0.990286894
p_ni:  0.009713067
p_wrong:  3.9e-8
Data Source:  BioPlex
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.987165522
p_ni:  0.012834478
Data Source:  BioPlex
DPP6
Tbio
Family:  Enzyme
Novelty:  0.00435138
p_int:  0.983802268
p_ni:  0.01583508
p_wrong:  0.000362652
Data Source:  BioPlex
UBB
Tbio
Novelty:  0.00661254
p_int:  0.981746002
p_ni:  0.018253998
Data Source:  BioPlex
PSG9
Tbio
Novelty:  0.0426075
p_int:  0.979154799
p_ni:  0.020842407
p_wrong:  0.000002794
Score:  0.202
Data Source:  BioPlex,STRINGDB
CHRNB1
Tclin
Family:  IC
Novelty:  0.04777051
p_int:  0.971266525
p_ni:  0.026659161
p_wrong:  0.002074314
Data Source:  BioPlex
ERAP1
Tchem
Family:  Enzyme
Novelty:  0.00404539
p_int:  0.966760407
p_ni:  0.03323856
p_wrong:  0.000001033
Score:  0.199
Data Source:  BioPlex,STRINGDB
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.959039527
p_ni:  0.040959241
p_wrong:  0.000001233
Data Source:  BioPlex
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
p_int:  0.955776898
p_ni:  0.044223099
p_wrong:  3e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
GBP5
Tbio
Novelty:  0.03705719
p_int:  0.934902466
p_ni:  0.062035741
p_wrong:  0.003061793
Score:  0.259
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
3
3
2
12.2
94.3
alkaline phosphatase measurement
2
2
1
7.8
88.6
aspartate aminotransferase measurement
2
2
1
7.5
87.4
heel bone mineral density
2
2
2
79.5
2
2
0
2.2
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
2
12.2
94.3
alkaline phosphatase measurement
1
7.8
88.6
aspartate aminotransferase measurement
1
7.5
87.4
heel bone mineral density
2
79.5
0
2.2
74.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein L2
VGNC:6687
741411
Macaque
apolipoprotein L2
694029
Mouse
MGI:1923011
75761
Rat
RGD:6490440
100911804
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein L2
Macaque
apolipoprotein L2
Mouse
Rat
Publication Statistics
PubMed Score 15.00
PubMed score by year
PubTator Score 6.41
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title