Protein Summary
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
- ENST00000319136
- ENSP00000317674
- ENSG00000100342
- ENST00000397278
- ENSP00000380448
- ENST00000397279
- ENSP00000380449
- ENST00000422706
- ENSP00000411507
- ENST00000426053
- ENSP00000388477
- APOL
- APOL
- APO-L
- FSGS4
- APOL-I
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.76 | ||
tissue sample | 0.75 | ||
cell type or tissue | 0.73 | ||
molecular function | 0.63 | ||
tissue | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 718.45 (req: < 5)
Gene RIFs: 158 (req: <= 3)
Antibodies: 381 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 718.45 (req: >= 5)
Gene RIFs: 158 (req: > 3)
Antibodies: 381 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (166)
Nearest Tclin Targets
Pathways (8)
Reactome (7)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (2)
Components (7)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 2 | 2 | 90.1 | |||||
mean corpuscular volume | 1 | 2 | 2 | 88.6 | |||||
heel bone mineral density | 2 | 2 | 2 | 79.5 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 77.3 | |||||
2 | 2 | 0 | 2.2 | 74.1 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 2 | 90.1 | |||||
mean corpuscular volume | 2 | 88.6 | |||||
heel bone mineral density | 2 | 79.5 | |||||
alkaline phosphatase measurement | 1 | 77.3 | |||||
0 | 2.2 | 74.1 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 718.45
PubMed score by year
PubTator Score 341.64
PubTator score by year
Related Publications
Text Mined References (175)
GeneRif Annotations (158)
Items per page:
0 of 0
PMID | Year | Title |
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