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Tbio
APOH
Beta-2-glycoprotein 1

Protein Summary
Description
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000205948
  • ENSP00000205948
  • ENSG00000091583

Symbol
  • B2G1
  • BG
  • B2G1
  • B2GP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.94
biological process
0.8
disease
0.69
molecular function
0.63
cell line
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1995.07   (req: < 5)
Gene RIFs: 167   (req: <= 3)
Antibodies: 502   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1995.07   (req: >= 5)
Gene RIFs: 167   (req: > 3)
Antibodies: 502   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
FLNA
Tbio
Novelty:  0.00156479
p_int:  0.921516266
p_ni:  0.078483734
Score:  0.485
Data Source:  BioPlex,STRINGDB
APOA1
Tbio
Novelty:  0.0001216
Score:  0.981
Data Source:  STRINGDB
APOC3
Tclin
Novelty:  0.0009635
Score:  0.978
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.973
Data Source:  STRINGDB
AHSG
Tbio
Novelty:  0.00112502
Score:  0.97
Data Source:  STRINGDB
APOA2
Tbio
Novelty:  0.00117627
Score:  0.97
Data Source:  STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.962
Data Source:  STRINGDB
ITIH3
Tbio
Novelty:  0.04201144
Score:  0.956
Data Source:  STRINGDB
AMBP
Tbio
Novelty:  0.00183885
Score:  0.954
Data Source:  STRINGDB
ITIH4
Tbio
Novelty:  0.00032471
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
93.6
C-reactive protein measurement
2
2
2
87.6
aspartate aminotransferase measurement
2
2
1
8.3
86.6
platelet crit
1
1
1
86.1
platelet count
1
1
1
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
93.6
C-reactive protein measurement
2
87.6
aspartate aminotransferase measurement
1
8.3
86.6
platelet crit
1
86.1
platelet count
1
83.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein H
VGNC:6341
468459
Mouse
MGI:88058
11818
Rat
RGD:1310625
287774
Dog
apolipoprotein H
VGNC:38004
403945
Horse
apolipoprotein H
VGNC:15423
100063250
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein H
Mouse
Rat
Dog
apolipoprotein H
Horse
apolipoprotein H
Publication Statistics
PubMed Score 1995.07
PubMed score by year
PubTator Score 1331.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title