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Tbio
APOF
Apolipoprotein F

Protein Summary
Description
Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII. The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398189
  • ENSP00000381250
  • ENSG00000175336

Symbol
  • LTIP
  • Apo-F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
cell type or tissue
0.61
PubMedID
0.51
tissue sample
0.51
disease perturbation
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.45   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.45   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
GALNT4
Tbio
Family:  Enzyme
Novelty:  0.05200323
p_int:  0.99999593
p_ni:  0.000004046
p_wrong:  2.3e-8
Score:  0.538
Data Source:  BioPlex,STRINGDB
CETP
Tchem
Novelty:  0.00051779
Score:  0.979
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.947
Data Source:  STRINGDB
APOA2
Tbio
Novelty:  0.00117627
Score:  0.884
Data Source:  STRINGDB
APOA1
Tbio
Novelty:  0.0001216
Score:  0.849
Data Source:  STRINGDB
APOM
Tbio
Novelty:  0.00505937
Score:  0.819
Data Source:  STRINGDB
APOC1
Tbio
Novelty:  0.00338935
Score:  0.817
Data Source:  STRINGDB
PLTP
Tbio
Novelty:  0.00267612
Score:  0.805
Data Source:  STRINGDB
APOC3
Tclin
Novelty:  0.0009635
Score:  0.8
Data Source:  STRINGDB
APOL1
Tbio
Novelty:  0.00176872
Score:  0.799
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
LDL remodeling (R-HSA-8964041)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
LDL remodeling
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
LDL remodeling
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
6
7
99.2
5
4
0
1.4
84.7
1
2
0
1.5
66.6
psoriasis vulgaris
1
1
0
1.4
63.7
lymphocyte percentage of leukocytes
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
7
99.2
0
1.4
84.7
0
1.5
66.6
psoriasis vulgaris
0
1.4
63.7
lymphocyte percentage of leukocytes
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein F
VGNC:4927
467203
Mouse
MGI:104539
103161
Rat
RGD:1560713
500761
Dog
apolipoprotein F
VGNC:38003
474405
Horse
apolipoprotein F
VGNC:15422
100059518
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein F
Mouse
Rat
Dog
apolipoprotein F
Horse
apolipoprotein F
Publication Statistics
PubMed Score 44.45
PubMed score by year
PubTator Score 20.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title