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Tbio
APOD
Apolipoprotein D

Protein Summary
Description
APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts. This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343267
  • ENSP00000345179
  • ENSG00000189058
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.94
PubMedID
0.94
virus perturbation
0.92
gene perturbation
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.87   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.87   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.999964102
p_ni:  0.000035898
Score:  0.237
Data Source:  BioPlex,STRINGDB
DHX57
Tdark
Family:  Enzyme
Novelty:  0.8244078
p_int:  0.999239114
p_ni:  0.000760886
Data Source:  BioPlex
KIAA0355
Tdark
Novelty:  0.97113831
p_int:  0.998065032
p_ni:  0.001934968
Score:  0.177
Data Source:  BioPlex,STRINGDB
ARHGAP36
Tbio
Family:  Enzyme
Novelty:  0.33342126
p_int:  0.995150931
p_ni:  0.004849069
Score:  0.153
Data Source:  BioPlex,STRINGDB
ALCAM
Tbio
Novelty:  0.00244371
p_int:  0.993578481
p_ni:  0.006152717
p_wrong:  0.000268803
Score:  0.284
Data Source:  BioPlex,STRINGDB
RPE
Tbio
Family:  Enzyme
Novelty:  0.01035554
p_int:  0.991020852
p_ni:  0.008979148
Score:  0.54
Data Source:  BioPlex,STRINGDB
SUMF2
Tbio
Family:  Enzyme
Novelty:  0.07551737
p_int:  0.98870425
p_ni:  0.01129575
Score:  0.295
Data Source:  BioPlex,STRINGDB
CFAP57
Tdark
Novelty:  0.33594432
p_int:  0.985123174
p_ni:  0.014876485
p_wrong:  3.41e-7
Data Source:  BioPlex
EFEMP1
Tbio
Novelty:  0.00574779
p_int:  0.960334038
p_ni:  0.039665962
Score:  0.211
Data Source:  BioPlex,STRINGDB
MAZ
Tbio
Family:  TF
Novelty:  0.00438101
p_int:  0.941616443
p_ni:  0.058383557
Score:  0.319
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of fatty acids
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of fatty acids
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
21.5
body height
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
21.5
body height
1
6.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein D
VGNC:1737
460951
Macaque
apolipoprotein D
709223
Mouse
MGI:88056
11815
Rat
RGD:2137
25239
Dog
apolipoprotein D
VGNC:38001
478604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein D
Macaque
apolipoprotein D
Mouse
Rat
Dog
apolipoprotein D
Publication Statistics
PubMed Score 350.87
PubMed score by year
PubTator Score 216.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title