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Tclin
APOC3
Apolipoprotein C-III

Protein Summary
Description
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013). This gene encodes a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227667
  • ENSP00000227667
  • ENSG00000110245

Symbol
  • APOCIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
biological process
0.99
biological term
0.93
co-expressed gene
0.82
disease
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1109.11   (req: < 5)
Gene RIFs: 214   (req: <= 3)
Antibodies: 379   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1109.11   (req: >= 5)
Gene RIFs: 214   (req: > 3)
Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (192)
ERN1
Tchem
Family:  Kinase
Novelty:  0.00141922
p_int:  0.999994085
p_ni:  0.000005915
Data Source:  BioPlex
PCYOX1
Tbio
Family:  Enzyme
Novelty:  0.18505748
p_int:  0.999300251
p_ni:  0.000699749
Score:  0.791
Data Source:  BioPlex,STRINGDB
CACNA2D1
Tclin
Family:  IC
Novelty:  0.01744541
p_int:  0.998567935
p_ni:  0.001432065
Data Source:  BioPlex
EMC1
Tbio
Novelty:  0.05360812
p_int:  0.996892258
p_ni:  0.003107743
Data Source:  BioPlex
ALG9
Tbio
Family:  Enzyme
Novelty:  0.02975572
p_int:  0.990051186
p_ni:  0.009948267
p_wrong:  5.47e-7
Data Source:  BioPlex
PDIA5
Tbio
Family:  Enzyme
Novelty:  0.06234465
p_int:  0.988587845
p_ni:  0.011412155
Data Source:  BioPlex
POMT1
Tbio
Family:  Enzyme
Novelty:  0.01971429
p_int:  0.982499625
p_ni:  0.017500375
Data Source:  BioPlex
ZMPSTE24
Tbio
Family:  Enzyme
Novelty:  0.0027993
p_int:  0.961131966
p_ni:  0.038677928
p_wrong:  0.000190106
Data Source:  BioPlex
GLG1
Tbio
Novelty:  0.01332149
p_int:  0.941309432
p_ni:  0.058690568
Data Source:  BioPlex
POMT2
Tbio
Family:  Enzyme
Novelty:  0.0251595
p_int:  0.929473975
p_ni:  0.070526025
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Chylomicron assembly (R-HSA-8963888)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chylomicron assembly
Reactome
Chylomicron remodeling
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
HDL remodeling
Name
Explore in Pharos
Explore in Source
Chylomicron assembly
Chylomicron remodeling
G alpha (i) signalling events
GPCR downstream signalling
HDL remodeling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (41)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred by Curator (IC)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (117)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
50
53
142
11
100
high density lipoprotein cholesterol measurement
28
32
77
1.8
99.9
low density lipoprotein cholesterol measurement
15
14
21
99.9
apolipoprotein A 1 measurement
2
12
13
99.8
total cholesterol measurement
14
22
38
3.5
99.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
142
11
100
high density lipoprotein cholesterol measurement
77
1.8
99.9
low density lipoprotein cholesterol measurement
21
99.9
apolipoprotein A 1 measurement
13
99.8
total cholesterol measurement
38
3.5
99.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein C3
VGNC:10231
107966396
Macaque
apolipoprotein C3
696726
Mouse
MGI:88055
11814
Rat
RGD:2136
24207
Dog
apolipoprotein C3
VGNC:38000
442970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein C3
Macaque
apolipoprotein C3
Mouse
Rat
Dog
apolipoprotein C3
Publication Statistics
PubMed Score 1109.11
PubMed score by year
PubTator Score 764.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title