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Tbio
APOBEC3F
DNA dC->dU-editing enzyme APOBEC-3F

Protein Summary
Description
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308521
  • ENSP00000309749
  • ENSG00000128394
  • ENST00000381565
  • ENSP00000370977

Symbol
  • A3F
  • KA6
  • ARP8
  • BK150C2.4.MRNA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.83
biological process
0.81
molecular function
0.67
biological term
0.65
tissue sample
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.2   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.2   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.999999872
p_ni:  1.1e-8
p_wrong:  1.17e-7
Score:  0.599
Data Source:  BioPlex,STRINGDB
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.999775512
p_ni:  0.000224457
p_wrong:  3e-8
Data Source:  BioPlex
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.999195433
p_ni:  0.000801742
p_wrong:  0.000002826
Score:  0.665
Data Source:  BioPlex,STRINGDB
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.991847167
p_ni:  0.008080925
p_wrong:  0.000071908
Score:  0.534
Data Source:  BioPlex,STRINGDB
TRA2A
Tbio
Novelty:  0.04935993
p_int:  0.959922116
p_ni:  0.022475239
p_wrong:  0.017602645
Score:  0.552
Data Source:  BioPlex,STRINGDB
RPL7A
Tbio
Novelty:  0.01674027
p_int:  0.864032252
p_ni:  0.126850411
p_wrong:  0.009117337
Data Source:  BioPlex
APOBEC3G
Tchem
Novelty:  0.00161191
Score:  0.852
Data Source:  STRINGDB
A1CF
Tbio
Novelty:  0.04151936
Score:  0.834
Data Source:  STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
Score:  0.826
Data Source:  STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
Score:  0.819
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
91.4
lymphocyte count
3
1
3
84
myeloid white cell count
1
1
1
77.6
monocyte count
1
1
1
76.1
leukocyte count
2
3
3
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
91.4
lymphocyte count
3
84
myeloid white cell count
1
77.6
monocyte count
1
76.1
leukocyte count
3
75.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 153.20
PubMed score by year
PubTator Score 74.13
PubTator score by year
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Related Publications
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PMID
Year
Title