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Tbio
APOBEC3D
DNA dC->dU-editing enzyme APOBEC-3D

Protein Summary
Description
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons. This gene is a member of the cytidine deaminase gene family. I ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216099
  • ENSP00000216099
  • ENSG00000243811

Symbol
  • A3D
  • ARP6
  • APOBEC3E
  • APOBEC3DE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.74
tissue sample
0.69
cell line
0.49
metabolite
0.45
tissue
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.64   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.64   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
APOBEC3F
Tbio
Novelty:  0.00603614
p_int:  0.999999872
p_ni:  1.1e-8
p_wrong:  1.17e-7
Score:  0.599
Data Source:  BioPlex,STRINGDB
RBMXL1
Tdark
Novelty:  0.81422952
p_int:  0.999999222
p_ni:  7.78e-7
Score:  0.363
Data Source:  BioPlex,STRINGDB
PPHLN1
Tbio
Novelty:  0.21311177
p_int:  0.999925426
p_ni:  0.000074574
Data Source:  BioPlex
SIPA1L2
Tbio
Novelty:  0.2002618
p_int:  0.999765944
p_ni:  0.000234034
p_wrong:  2.3e-8
Data Source:  BioPlex
YTHDC1
Tbio
Novelty:  0.0156474
p_int:  0.999455736
p_ni:  0.000544214
p_wrong:  4.9e-8
Score:  0.192
Data Source:  BioPlex,STRINGDB
SLTM
Tbio
Novelty:  0.09563037
p_int:  0.999099401
p_ni:  0.000900599
Data Source:  BioPlex
DNAJB5
Tbio
Novelty:  0.20703358
p_int:  0.998477281
p_ni:  0.001522719
Data Source:  BioPlex
HELZ2
Tdark
Family:  Enzyme
Novelty:  0.1810765
p_int:  0.998431116
p_ni:  0.001568758
p_wrong:  1.26e-7
Data Source:  BioPlex
SAFB2
Tbio
Novelty:  0.12354864
p_int:  0.998154039
p_ni:  0.001845961
Data Source:  BioPlex
KIF23
Tbio
Novelty:  0.00719651
p_int:  0.997715054
p_ni:  0.002284946
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
76.1
red blood cell distribution width
2
2
3
61.4
hematocrit
1
1
1
53.3
hemoglobin measurement
1
1
1
52
neutrophil count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
76.1
red blood cell distribution width
3
61.4
hematocrit
1
53.3
hemoglobin measurement
1
52
neutrophil count
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1933111
80287
Rat
RGD:1307800
315137
Horse
apolipoprotein B mRNA editing enzyme, catalytic polypeptide
100070250
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
apolipoprotein B mRNA editing enzyme, catalytic polypeptide
Publication Statistics
PubMed Score 87.64
PubMed score by year
PubTator Score 79.63
PubTator score by year
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Related Publications
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PMID
Year
Title