Tchem APOBEC3A DNA dC->dU-editing enzyme APOBEC-3A

Protein Summary

Description

DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this gene is the same as that encoded by APOBEC3A; however, this gene is a hybrid gene that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• P31941
• A0AVM1
• Q12807
• Q5JZ93
• Q9UH18
• A3A

Gene Name

• APOBEC3A

Ensembl ID

• ENST00000249116
• ENSP00000249116
• ENSG00000128383
• ENST00000402255
• ENSP00000384359
• ENST00000570508
• ENSP00000461288
• ENSG00000262156
• ENST00000618553
• ENSP00000481904
• ENST00000623492
• ENSP00000485234

Symbol

• A3A
• APOBEC3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.66
microRNA	0.59
virus perturbation	0.59
biological term	0.56
tissue sample	0.49

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Dc->du-editing Enzyme Apobec-3a

Protein / Hydrolase / Deaminase / Dna Dc->du-editing Enzyme Apobec-3a

DTO Classes

Protein / Enzyme / Hydrolase / Deaminase / Dna Dc->du-editing Enzyme Apobec-3a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.28   (req: < 5)

Gene RIFs: 123   (req: <= 3)

Antibodies: 227   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.28   (req: >= 5)

Gene RIFs: 123   (req: > 3)

Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0