Tbio APOA5 Apolipoprotein A-V

Protein Summary

Description

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q6Q788
• B0YIV9
• Q3MIK6
• Q6UWK9
• Q9UBJ3
• Apo-AV

Gene Name

• APOA5

Ensembl ID

• ENST00000227665
• ENSP00000227665
• ENSG00000110243
• ENST00000542499
• ENSP00000445002

Symbol

• RAP3
• RAP3
• APOAV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1
biological process	0.98
biological term	0.98
molecular function	0.98
trait	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 513.82   (req: < 5)

Gene RIFs: 314   (req: <= 3)

Antibodies: 686   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 513.82   (req: >= 5)

Gene RIFs: 314   (req: > 3)

Antibodies: 686   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (234)

Explore Interacting Targets

1 – 10 of 234

• See Interactions on String-DB

APOC3

Tclin

Novelty:  0.0009635

Score:  0.991

Data Source:  STRINGDB

GPIHBP1

Tbio

Novelty:  0.01241227

Score:  0.988

Data Source:  STRINGDB

LPL

Tchem

Family:  Enzyme

Novelty:  0.00057058

Score:  0.982

Data Source:  STRINGDB

APOB

Tchem

Novelty:  0.00008247

Score:  0.981

Data Source:  STRINGDB

APOC2

Tbio

Novelty:  0.0015496

Score:  0.98

Data Source:  STRINGDB

CREB3L3

Tbio

Family:  TF

Novelty:  0.02519904

Score:  0.973

Data Source:  STRINGDB

APOE

Tbio

Novelty:  0.00005049

Score:  0.97

Data Source:  STRINGDB

SERPINC1

Tclin

Novelty:  0.00008721

Score:  0.97

Data Source:  STRINGDB

APOA2

Tbio

Novelty:  0.00117627

Score:  0.969

Data Source:  STRINGDB

PPARA

Tclin

Family:  NR

Novelty:  0.00017403

Score:  0.968

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (18)

Reactome (13)

KEGG (1)

WikiPathways (4)

Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 13

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Assembly of active LPL and LIPC lipase complexes	19 targets	R-HSA-8963889
Reactome	Chylomicron remodeling	10 targets	R-HSA-8963901
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Assembly of active LPL and LIPC lipase complexes	19 targets	R-HSA-8963889
Chylomicron remodeling	10 targets	R-HSA-8963901
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (48)

Functions (14)

Components (6)

Processes (28)

Find Similar Targets

Items per page:

10

1 – 10 of 14

GO Term	Evidence	Assigned by
enzyme activator activity	Inferred from Direct Assay (IDA)	BHF-UCL
enzyme binding	Inferred from Direct Assay (IDA)	BHF-UCL
heparin binding	Inferred from Direct Assay (IDA)	BHF-UCL
lipid binding	Inferred from Direct Assay (IDA)	UniProtKB
lipoprotein lipase activator activity	Inferred from Direct Assay (IDA)	BHF-UCL
phosphatidylcholine binding	Inferred from Direct Assay (IDA)	BHF-UCL
phospholipid binding	Inferred from Direct Assay (IDA)	BHF-UCL
lipase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
lipoprotein particle receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
low-density lipoprotein particle receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (122)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 122

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	53	61	161	13.1	100
high density lipoprotein cholesterol measurement	EFO_0004612	30	36	85	1.8	99.9
low density lipoprotein cholesterol measurement	EFO_0004611	15	14	21		99.9
apolipoprotein A 1 measurement	EFO_0004614	2	12	13		99.8
total cholesterol measurement	EFO_0004574	14	24	39	3.5	99.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 122

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	161	13.1	100
high density lipoprotein cholesterol measurement	EFO_0004612	85	1.8	99.9
low density lipoprotein cholesterol measurement	EFO_0004611	21		99.9
apolipoprotein A 1 measurement	EFO_0004614	13		99.8
total cholesterol measurement	EFO_0004574	39	3.5	99.6

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Chylomicron
Coiled coil
Complete proteome
Disease mutation
HDL
Lipid transport
Phosphoprotein
Polymorphism
Reference proteome
Secreted

GWAS Trait Find Similar Targets

No Header	No Header
Abdominal Aortic Aneurysm
adiponectin measurement
Agents acting on the renin-angiotensin system use measurement
alkaline phosphatase measurement
amino acid measurement
antioxidant measurement
Antithrombotic agent use measurement
apolipoprotein A 1 measurement
apolipoprotein A-IV measurement
apolipoprotein B measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	apolipoprotein A5	VGNC:10230	466791
Mouse	apolipoprotein A-V	MGI:1913363	66113
Rat	apolipoprotein A5	RGD:70903	140638
Dog	apolipoprotein A5	VGNC:37993	489393
Horse	apolipoprotein A5	VGNC:15415	100071101

Species	Name	OMA	EggNOG	Inparanoid
Chimp	apolipoprotein A5
Mouse	apolipoprotein A-V
Rat	apolipoprotein A5
Dog	apolipoprotein A5
Horse	apolipoprotein A5

Publication Statistics

PubMed Score 513.82

PubMed score by year

Reset Zoom

PubTator Score 402.26

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (413)

GeneRif Annotations (314)

Items per page:

10

0 of 0

PMID	Year	Title