Tbio APOA5 Apolipoprotein A-V

Protein Summary

Description

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q6Q788
• B0YIV9
• Q3MIK6
• Q6UWK9
• Q9UBJ3
• Apo-AV

Gene Name

• APOA5

Ensembl ID

• ENST00000227665
• ENSP00000227665
• ENSG00000110243
• ENST00000542499
• ENSP00000445002

Symbol

• RAP3
• RAP3
• APOAV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1
biological process	0.98
biological term	0.98
molecular function	0.98
trait	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 545.39   (req: < 5)

Gene RIFs: 353   (req: <= 3)

Antibodies: 686   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 545.39   (req: >= 5)

Gene RIFs: 353   (req: > 3)

Antibodies: 686   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0