Protein Summary
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromoso ...more
- ENST00000227665
- ENSP00000227665
- ENSG00000110243
- ENST00000542499
- ENSP00000445002
- RAP3
- RAP3
- APOAV
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
metabolite | 1 | ||
biological process | 0.98 | ||
biological term | 0.98 | ||
molecular function | 0.98 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 513.82 (req: < 5)
Gene RIFs: 314 (req: <= 3)
Antibodies: 686 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 513.82 (req: >= 5)
Gene RIFs: 314 (req: > 3)
Antibodies: 686 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 42
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (234)
Nearest Tclin Targets
Pathways (18)
Reactome (13)
KEGG (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Assembly of active LPL and LIPC lipase complexes | ||||
Reactome | Chylomicron remodeling | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Assembly of active LPL and LIPC lipase complexes | ||||
Chylomicron remodeling | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (48)
Functions (14)
Components (6)
Processes (28)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (122)
Items per page:
1 – 5 of 122
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 53 | 61 | 161 | 13.1 | 100 | ||||
high density lipoprotein cholesterol measurement | 30 | 36 | 85 | 1.8 | 99.9 | ||||
low density lipoprotein cholesterol measurement | 15 | 14 | 21 | 99.9 | |||||
apolipoprotein A 1 measurement | 2 | 12 | 13 | 99.8 | |||||
total cholesterol measurement | 14 | 24 | 39 | 3.5 | 99.6 | ||||
Items per page:
1 – 5 of 122
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
triglyceride measurement | 161 | 13.1 | 100 | ||||
high density lipoprotein cholesterol measurement | 85 | 1.8 | 99.9 | ||||
low density lipoprotein cholesterol measurement | 21 | 99.9 | |||||
apolipoprotein A 1 measurement | 13 | 99.8 | |||||
total cholesterol measurement | 39 | 3.5 | 99.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | apolipoprotein A5 | VGNC:10230 | 466791 | |||||
Mouse | MGI:1913363 | 66113 | ||||||
Rat | RGD:70903 | 140638 | ||||||
Dog | apolipoprotein A5 | VGNC:37993 | 489393 | |||||
Horse | apolipoprotein A5 | VGNC:15415 | 100071101 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | apolipoprotein A5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | apolipoprotein A5 | |||||
Horse | apolipoprotein A5 | |||||
Publication Statistics
PubMed Score 513.82
PubMed score by year
PubTator Score 402.26
PubTator score by year
Related Publications
Text Mined References (413)
GeneRif Annotations (314)
Items per page:
0 of 0
PMID | Year | Title |
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