Protein Summary
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of whic ...more
- ENST00000236850
- ENSP00000236850
- ENSG00000118137
- ENST00000359492
- ENSP00000352471
- ENST00000375320
- ENSP00000364469
- ENST00000375323
- ENSP00000364472
- apo(a)
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
metabolite | 1 | ||
molecular function | 1 | ||
chemical | 0.98 | ||
virus perturbation | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8382.57 (req: < 5)
Gene RIFs: 673 (req: <= 3)
Antibodies: 1476 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8382.57 (req: >= 5)
Gene RIFs: 673 (req: > 3)
Antibodies: 1476 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 77
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (346)
GDPD1
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999999931
p_ni: 6.9e-8
p_wrong: 1e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
MAPK6
Family: Kinase
Novelty: 0.01012514
p_int: 0.999996099
p_ni: 0.000003897
p_wrong: 5e-9
Data Source: BioPlex
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999658758
p_ni: 0.000340924
p_wrong: 3.18e-7
Data Source: BioPlex
ZNF558
Family: TF
Novelty: 0.821338
p_int: 0.999627071
p_ni: 0.000372898
p_wrong: 3.1e-8
Score: 0.261
Data Source: BioPlex,STRINGDB
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999606394
p_ni: 0.000393252
p_wrong: 3.54e-7
Data Source: BioPlex
ALDH2
Family: Enzyme
Novelty: 0.00077122
p_int: 0.999520818
p_ni: 0.000478844
p_wrong: 3.38e-7
Score: 0.318
Data Source: BioPlex,STRINGDB
GOT1L1
Family: Enzyme
Novelty: 0.52342415
p_int: 0.979894155
p_ni: 0.020099999
p_wrong: 0.000005846
Score: 0.213
Data Source: BioPlex,STRINGDB
UPF3A
Novelty: 0.01431609
p_int: 0.979567567
p_ni: 0.02043017
p_wrong: 0.000002263
Score: 0.169
Data Source: BioPlex,STRINGDB
VCAM1
Novelty: 0.00022504
p_int: 0.918577288
p_ni: 0.081422164
p_wrong: 5.48e-7
Score: 0.733
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (58)
Reactome (42)
KEGG (5)
PathwayCommons (1)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ABC transporter disorders | ||||
Reactome | ABC transporters in lipid homeostasis | ||||
Reactome | ABC-family proteins mediated transport | ||||
Reactome | Amyloid fiber formation | ||||
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ABC transporter disorders | ||||
ABC transporters in lipid homeostasis | ||||
ABC-family proteins mediated transport | ||||
Amyloid fiber formation | ||||
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (100)
Functions (15)
Components (23)
Processes (62)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (115)
Items per page:
1 – 5 of 115
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 49 | 52 | 142 | 9 | 100 | ||||
high density lipoprotein cholesterol measurement | 28 | 32 | 77 | 1.8 | 99.9 | ||||
low density lipoprotein cholesterol measurement | 14 | 13 | 20 | 99.8 | |||||
apolipoprotein A 1 measurement | 2 | 12 | 13 | 99.8 | |||||
total cholesterol measurement | 14 | 22 | 38 | 3.5 | 99.6 | ||||
Items per page:
1 – 5 of 115
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
triglyceride measurement | 142 | 9 | 100 | ||||
high density lipoprotein cholesterol measurement | 77 | 1.8 | 99.9 | ||||
low density lipoprotein cholesterol measurement | 20 | 99.8 | |||||
apolipoprotein A 1 measurement | 13 | 99.8 | |||||
total cholesterol measurement | 38 | 3.5 | 99.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | apolipoprotein A1 | VGNC:10228 | 107967226 | |||||
Mouse | MGI:88049 | 11806 | ||||||
Rat | RGD:2130 | 25081 | ||||||
Dog | apolipoprotein A1 | VGNC:37991 | 479427 | |||||
Horse | apolipoprotein A1 | VGNC:15413 | 100062583 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | apolipoprotein A1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | apolipoprotein A1 | |||||
Horse | apolipoprotein A1 | |||||
Publication Statistics
PubMed Score 8382.57
PubMed score by year
PubTator Score 6595.32
PubTator score by year
Related Publications
Text Mined References (930)
GeneRif Annotations (673)
Items per page:
0 of 0
PMID | Year | Title |
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