Tbio APOA1 Apolipoprotein A-I

Protein Summary

Description

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• P02647
• A8K866
• Q6LDN9
• Q6Q785
• Q9UCS8
• Q9UCT8
• Apo-AI

Gene Name

• APOA1

Ensembl ID

• ENST00000236850
• ENSP00000236850
• ENSG00000118137
• ENST00000359492
• ENSP00000352471
• ENST00000375320
• ENSP00000364469
• ENST00000375323
• ENSP00000364472

Symbol

• apo(a)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
metabolite	1
molecular function	1
chemical	0.98
virus perturbation	0.92

Protein Classes

DTO Classes

Apolipoprotein A-ii

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8859.73   (req: < 5)

Gene RIFs: 786   (req: <= 3)

Antibodies: 1476   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8859.73   (req: >= 5)

Gene RIFs: 786   (req: > 3)

Antibodies: 1476   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 77

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0