Tbio APOA1 Apolipoprotein A-I

Protein Summary

Description

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• P02647
• A8K866
• Q6LDN9
• Q6Q785
• Q9UCS8
• Q9UCT8
• Apo-AI

Gene Name

• APOA1

Ensembl ID

• ENST00000236850
• ENSP00000236850
• ENSG00000118137
• ENST00000359492
• ENSP00000352471
• ENST00000375320
• ENSP00000364469
• ENST00000375323
• ENSP00000364472

Symbol

• apo(a)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
metabolite	1
molecular function	1
chemical	0.98
virus perturbation	0.92

Protein Classes

DTO Classes

Apolipoprotein A-ii

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8859.73   (req: < 5)

Gene RIFs: 673   (req: <= 3)

Antibodies: 1476   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8859.73   (req: >= 5)

Gene RIFs: 673   (req: > 3)

Antibodies: 1476   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 77

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (346)

Explore Interacting Targets

1 – 10 of 346

• See Interactions on String-DB

GDPD1

Tbio

Family:  Enzyme

Novelty:  0.28722153

p_int:  0.999999931

p_ni:  6.9e-8

p_wrong:  1e-9

Score:  0.177

Data Source:  BioPlex,STRINGDB

SNX27

Tbio

Novelty:  0.02419724

p_int:  0.999999107

p_ni:  8.92e-7

p_wrong:  2e-9

Data Source:  BioPlex

MAPK6

Tchem

Family:  Kinase

Novelty:  0.01012514

p_int:  0.999996099

p_ni:  0.000003897

p_wrong:  5e-9

Data Source:  BioPlex

DDX19B

Tbio

Family:  Enzyme

Novelty:  0.0504568

p_int:  0.999658758

p_ni:  0.000340924

p_wrong:  3.18e-7

Data Source:  BioPlex

ZNF558

Tdark

Family:  TF

Novelty:  0.821338

p_int:  0.999627071

p_ni:  0.000372898

p_wrong:  3.1e-8

Score:  0.261

Data Source:  BioPlex,STRINGDB

DDX31

Tbio

Family:  Enzyme

Novelty:  2.84646195

p_int:  0.999606394

p_ni:  0.000393252

p_wrong:  3.54e-7

Data Source:  BioPlex

ALDH2

Tclin

Family:  Enzyme

Novelty:  0.00077122

p_int:  0.999520818

p_ni:  0.000478844

p_wrong:  3.38e-7

Score:  0.318

Data Source:  BioPlex,STRINGDB

GOT1L1

Tdark

Family:  Enzyme

Novelty:  0.52342415

p_int:  0.979894155

p_ni:  0.020099999

p_wrong:  0.000005846

Score:  0.213

Data Source:  BioPlex,STRINGDB

UPF3A

Tbio

Novelty:  0.01431609

p_int:  0.979567567

p_ni:  0.02043017

p_wrong:  0.000002263

Score:  0.169

Data Source:  BioPlex,STRINGDB

VCAM1

Tchem

Novelty:  0.00022504

p_int:  0.918577288

p_ni:  0.081422164

p_wrong:  5.48e-7

Score:  0.733

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (58)

Reactome (42)

KEGG (5)

PathwayCommons (1)

WikiPathways (10)

ABC transporter disorders (R-HSA-5619084)

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1 – 5 of 42

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ABC transporter disorders	78 targets	R-HSA-5619084
Reactome	ABC transporters in lipid homeostasis	18 targets	R-HSA-1369062
Reactome	ABC-family proteins mediated transport	104 targets	R-HSA-382556
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225
Reactome	Binding and Uptake of Ligands by Scavenger Receptors	116 targets	R-HSA-2173782

Name	Explore in Pharos	Explore in Source
ABC transporter disorders	78 targets	R-HSA-5619084
ABC transporters in lipid homeostasis	18 targets	R-HSA-1369062
ABC-family proteins mediated transport	104 targets	R-HSA-382556
Amyloid fiber formation	79 targets	R-HSA-977225
Binding and Uptake of Ligands by Scavenger Receptors	116 targets	R-HSA-2173782

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (100)

Functions (15)

Components (23)

Processes (62)

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Items per page:

10

1 – 10 of 15

GO Term	Evidence	Assigned by
amyloid-beta binding	Inferred from Direct Assay (IDA)	BHF-UCL
chemorepellent activity	Inferred from Direct Assay (IDA)	UniProtKB
cholesterol binding	Inferred from Direct Assay (IDA)	BHF-UCL
phosphatidylcholine-sterol O-acyltransferase activator activity	Inferred from Direct Assay (IDA)	BHF-UCL
phospholipid binding	Inferred from Direct Assay (IDA)	BHF-UCL
apolipoprotein A-I receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
apolipoprotein receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
enzyme binding	Inferred from Physical Interaction (IPI)	BHF-UCL
heat shock protein binding	Inferred from Physical Interaction (IPI)	CAFA
high-density lipoprotein particle receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Disease Associations (null)

No disease associations found

GWAS Traits (189)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 189

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	141	80	611	8.8	100
high density lipoprotein cholesterol measurement	EFO_0004612	90	41	180	1.8	100
total cholesterol measurement	EFO_0004574	32	28	62	3.5	99.9
low density lipoprotein cholesterol measurement	EFO_0004611	57	22	84		99.9
metabolic syndrome	EFO_0000195	7	8	10	1.3	99.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	611	8.8	100
high density lipoprotein cholesterol measurement	EFO_0004612	180	1.8	100
total cholesterol measurement	EFO_0004574	62	3.5	99.9
low density lipoprotein cholesterol measurement	EFO_0004611	84		99.9
metabolic syndrome	EFO_0000195	10	1.3	99.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Amyloid
Amyloidosis
Atherosclerosis
Cholesterol metabolism
Complete proteome
Direct protein sequencing
Disease mutation
Glycation
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
3-hydroxybutyrate measurement
Abdominal Aortic Aneurysm
acetoacetate measurement
acetone measurement
adiponectin measurement
Agents acting on the renin-angiotensin system use measurement
alanine measurement
amino acid measurement
antioxidant measurement
Antithrombotic agent use measurement

MGI Phenotype Find Similar Targets

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cardiovascular system phenotype
cellular phenotype
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	apolipoprotein A1	VGNC:10228	107967226
Mouse	apolipoprotein A-I	MGI:88049	11806
Rat	apolipoprotein A1	RGD:2130	25081
Dog	apolipoprotein A1	VGNC:37991	479427
Horse	apolipoprotein A1	VGNC:15413	100062583

Species	Name	OMA	EggNOG	Inparanoid
Chimp	apolipoprotein A1
Mouse	apolipoprotein A-I
Rat	apolipoprotein A1
Dog	apolipoprotein A1
Horse	apolipoprotein A1

Publication Statistics

PubMed Score 8859.73

PubMed score by year

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PubTator Score 6595.32

PubTator score by year

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Related Publications

Text Mined References (930)

GeneRif Annotations (673)

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PMID	Year	Title