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Tbio
APOA1
Apolipoprotein A-I

Protein Summary
Description
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of whic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236850
  • ENSP00000236850
  • ENSG00000118137
  • ENST00000359492
  • ENSP00000352471
  • ENST00000375320
  • ENSP00000364469
  • ENST00000375323
  • ENSP00000364472

Symbol
  • apo(a)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
metabolite
1
molecular function
1
chemical
0.98
virus perturbation
0.92


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8859.73   (req: < 5)
Gene RIFs: 673   (req: <= 3)
Antibodies: 1476   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8859.73   (req: >= 5)
Gene RIFs: 673   (req: > 3)
Antibodies: 1476   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 77
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (346)
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.999999931
p_ni:  6.9e-8
p_wrong:  1e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999999107
p_ni:  8.92e-7
p_wrong:  2e-9
Data Source:  BioPlex
MAPK6
Tchem
Family:  Kinase
Novelty:  0.01012514
p_int:  0.999996099
p_ni:  0.000003897
p_wrong:  5e-9
Data Source:  BioPlex
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.999658758
p_ni:  0.000340924
p_wrong:  3.18e-7
Data Source:  BioPlex
ZNF558
Tdark
Family:  TF
Novelty:  0.821338
p_int:  0.999627071
p_ni:  0.000372898
p_wrong:  3.1e-8
Score:  0.261
Data Source:  BioPlex,STRINGDB
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999606394
p_ni:  0.000393252
p_wrong:  3.54e-7
Data Source:  BioPlex
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
p_int:  0.999520818
p_ni:  0.000478844
p_wrong:  3.38e-7
Score:  0.318
Data Source:  BioPlex,STRINGDB
GOT1L1
Tdark
Family:  Enzyme
Novelty:  0.52342415
p_int:  0.979894155
p_ni:  0.020099999
p_wrong:  0.000005846
Score:  0.213
Data Source:  BioPlex,STRINGDB
UPF3A
Tbio
Novelty:  0.01431609
p_int:  0.979567567
p_ni:  0.02043017
p_wrong:  0.000002263
Score:  0.169
Data Source:  BioPlex,STRINGDB
VCAM1
Tchem
Novelty:  0.00022504
p_int:  0.918577288
p_ni:  0.081422164
p_wrong:  5.48e-7
Score:  0.733
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (58)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Amyloid fiber formation
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Amyloid fiber formation
Binding and Uptake of Ligands by Scavenger Receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (100)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (189)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
141
80
611
8.8
100
high density lipoprotein cholesterol measurement
90
41
180
1.8
100
total cholesterol measurement
32
28
62
3.5
99.9
low density lipoprotein cholesterol measurement
57
22
84
99.9
metabolic syndrome
7
8
10
1.3
99.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
611
8.8
100
high density lipoprotein cholesterol measurement
180
1.8
100
total cholesterol measurement
62
3.5
99.9
low density lipoprotein cholesterol measurement
84
99.9
metabolic syndrome
10
1.3
99.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein A1
VGNC:10228
107967226
Mouse
MGI:88049
11806
Rat
RGD:2130
25081
Dog
apolipoprotein A1
VGNC:37991
479427
Horse
apolipoprotein A1
VGNC:15413
100062583
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein A1
Mouse
Rat
Dog
apolipoprotein A1
Horse
apolipoprotein A1
Publication Statistics
PubMed Score 8859.73
PubMed score by year
PubTator Score 6595.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title