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Tchem
APLNR
Apelin receptor

Protein Summary
Description
Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:110901 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257254
  • ENSP00000257254
  • ENSG00000134817
  • ENST00000606794
  • ENSP00000475344
  • ENST00000611099
  • ENSP00000477818

Symbol
  • AGTRL1
  • APJ
  • APJ
  • APJR
  • HG11
  • AGTRL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
biological term
0.62
tissue sample
0.61
protein domain
0.58
ligand (chemical)
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 549.83   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 517   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 549.83   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 248
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0