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Tbio
APLF
Aprataxin and PNK-like factor

Protein Summary
Description
Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303795
  • ENSP00000307004
  • ENSG00000169621

Symbol
  • C2orf13
  • PALF
  • XIP1
  • APFL
  • PALF
  • Xip1
  • ZCCHH1
  • C2orf13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
histone modification site profile
0.84
molecular function
0.79
transcription factor binding site profile
0.74
microRNA
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.23   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.23   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
POLB
Tchem
Family:  Enzyme
Novelty:  0.00145102
p_int:  1
Score:  0.835
Data Source:  BioPlex,STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
p_int:  0.999999999
p_ni:  1e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
LIG3
Tbio
Family:  Enzyme
Novelty:  0.00809038
p_int:  0.999999909
p_ni:  9.1e-8
Score:  0.766
Data Source:  BioPlex,STRINGDB
XRCC1
Tbio
Novelty:  0.00084203
p_int:  0.999996794
p_ni:  0.000003205
p_wrong:  2e-9
Score:  0.986
Data Source:  BioPlex,STRINGDB
XPC
Tbio
Novelty:  0.00775175
p_int:  0.999982116
p_ni:  0.000017884
Score:  0.78
Data Source:  BioPlex,STRINGDB
PARP2
Tclin
Family:  Enzyme
Novelty:  0.00545618
p_int:  0.999977284
p_ni:  0.000022716
Score:  0.822
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.999964233
p_ni:  0.000035757
p_wrong:  1e-8
Score:  0.551
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999931503
p_ni:  0.00006523
p_wrong:  0.000003267
Score:  0.671
Data Source:  BioPlex,STRINGDB
LIG4
Tbio
Family:  Enzyme
Novelty:  0.00412993
p_int:  0.999849717
p_ni:  0.000124037
p_wrong:  0.000026246
Score:  0.989
Data Source:  BioPlex,STRINGDB
TDP1
Tchem
Family:  Enzyme
Novelty:  0.00607344
p_int:  0.99969278
p_ni:  0.000304918
p_wrong:  0.000002303
Score:  0.776
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
4
90.4
lymphocyte count
3
1
3
81.1
mean platelet volume
2
1
2
77.4
alkaline phosphatase measurement
2
2
1
5.8
75.4
eosinophil percentage of leukocytes
1
1
1
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
4
90.4
lymphocyte count
3
81.1
mean platelet volume
2
77.4
alkaline phosphatase measurement
1
5.8
75.4
eosinophil percentage of leukocytes
1
74.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919353
72103
Rat
RGD:1565557
500247
Dog
aprataxin and PNKP like factor
VGNC:53960
481405
Horse
aprataxin and PNKP like factor
VGNC:51276
100061683
Cow
aprataxin and PNKP like factor
507989
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
aprataxin and PNKP like factor
Horse
aprataxin and PNKP like factor
Cow
aprataxin and PNKP like factor
Publication Statistics
PubMed Score 75.23
PubMed score by year
PubTator Score 36.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title