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Tbio
API5
Apoptosis inhibitor 5

Protein Summary
Description
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378852
  • ENSP00000368129
  • ENSG00000166181
  • ENST00000420461
  • ENSP00000402540
  • ENST00000455725
  • ENSP00000399341
  • ENST00000531273
  • ENSP00000431391

Symbol
  • AAC11
  • AAC-11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
interacting protein
0.95
transcription factor binding site profile
0.83
disease perturbation
0.74
drug perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.01   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.01   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.988
Data Source:  STRINGDB
TBC1D23
Tbio
Novelty:  0.18566729
Score:  0.92
Data Source:  STRINGDB
GLRX3
Tbio
Novelty:  0.0096265
Score:  0.866
Data Source:  STRINGDB
PPP2R5E
Tbio
Family:  Enzyme
Novelty:  0.05974697
Score:  0.861
Data Source:  STRINGDB
OSGEP
Tbio
Family:  Enzyme
Novelty:  0.0106198
Score:  0.859
Data Source:  STRINGDB
ACIN1
Tbio
Novelty:  0.01675479
Score:  0.761
Data Source:  STRINGDB
FGF2
Tchem
Novelty:  0.00007856
Score:  0.717
Data Source:  STRINGDB
RBM25
Tbio
Novelty:  0.05557892
Score:  0.714
Data Source:  STRINGDB
SF3A1
Tbio
Novelty:  0.03405702
Score:  0.701
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.685
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error
2
2
1
5.5
48.6
educational attainment
1
1
1
25.8
mathematical ability
1
1
1
22.8
age at onset
1
1
0
5.5
2.4
Myopia
1
1
0
5.5
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error
1
5.5
48.6
educational attainment
1
25.8
mathematical ability
1
22.8
age at onset
0
5.5
2.4
Myopia
0
5.5
2.4
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apoptosis inhibitor 5
VGNC:11259
451131
Macaque
apoptosis inhibitor 5
716346
Mouse
MGI:1888993
11800
Rat
RGD:1309772
362170
Dog
apoptosis inhibitor 5
VGNC:37985
483413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apoptosis inhibitor 5
Macaque
apoptosis inhibitor 5
Mouse
Rat
Dog
apoptosis inhibitor 5
Publication Statistics
PubMed Score 84.01
PubMed score by year
PubTator Score 46.42
PubTator score by year
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Related Publications
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PMID
Year
Title