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Tchem
APEX1
DNA-(apurinic or apyrimidinic site) lyase

Protein Summary
Description
Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216714
  • ENSP00000216714
  • ENSG00000100823
  • ENST00000398030
  • ENSP00000381111
  • ENST00000555414
  • ENSP00000451979

Symbol
  • APE
  • APE1
  • APEX
  • APX
  • HAP1
  • REF1
  • APE
  • APX
  • APE1
  • APEN
  • APEX
  • HAP1
  • REF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.99
disease perturbation
0.97
kinase perturbation
0.96
phenotype
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3048.7   (req: < 5)
Gene RIFs: 405   (req: <= 3)
Antibodies: 810   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3048.7   (req: >= 5)
Gene RIFs: 405   (req: > 3)
Antibodies: 810   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (24)
myricetin
Rendered image for myricetin
Aurintricarboxylic acid
Rendered image for Aurintricarboxylic acid
Tanshinone IIA
Rendered image for Tanshinone IIA
SID26666750
Rendered image for SID26666750
Reactive Blue 2
Rendered image for Reactive Blue 2
Methyl-3,4-dephostatin
Rendered image for Methyl-3,4-dephostatin
CHEMBL578390
Rendered image for CHEMBL578390
CHEMBL4210534
Rendered image for CHEMBL4210534
CHEMBL4205402
Rendered image for CHEMBL4205402
Protein-Protein Interactions (259)
KLHL36
Tdark
Novelty:  1.4153425
p_int:  0.999976159
p_ni:  0.000023841
Score:  0.345
Data Source:  BioPlex,STRINGDB
FCGR2A
Tbio
Novelty:  0.00078918
p_int:  0.999590465
p_ni:  0.000409535
Score:  0.404
Data Source:  BioPlex,STRINGDB
NTHL1
Tbio
Family:  Enzyme
Novelty:  0.00769394
Score:  0.997
Data Source:  Reactome,STRINGDB
OGG1
Tchem
Family:  Enzyme
Novelty:  0.00074509
Score:  0.995
Data Source:  Reactome,STRINGDB
FEN1
Tchem
Family:  Enzyme
Novelty:  0.00082515
Score:  0.992
Data Source:  Reactome,STRINGDB
LIG1
Tchem
Family:  Enzyme
Novelty:  0.00326816
Score:  0.988
Data Source:  Reactome,STRINGDB
POLB
Tchem
Family:  Enzyme
Novelty:  0.00145102
Score:  0.986
Data Source:  Reactome,STRINGDB
TDG
Tbio
Family:  Enzyme
Novelty:  0.00283178
Score:  0.982
Data Source:  Reactome,STRINGDB
SET
Tbio
Novelty:  0.01012327
Score:  0.982
Data Source:  STRINGDB
ANP32A
Tbio
Novelty:  0.00567095
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (R-HSA-73930)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Reactome
Base Excision Repair
Reactome
DNA Repair
Reactome
Displacement of DNA glycosylase by APEX1
Reactome
PCNA-Dependent Long Patch Base Excision Repair
Name
Explore in Pharos
Explore in Source
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Base Excision Repair
DNA Repair
Displacement of DNA glycosylase by APEX1
PCNA-Dependent Long Patch Base Excision Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (51)
Find Similar Targets
Items per page:
10
1 – 10 of 23
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
1
1
73.6
metabolite measurement
1
1
1
65.6
aspartate aminotransferase measurement
2
1
1
6.8
62.1
1
1
0
1.6
27.3
serum alanine aminotransferase measurement
1
1
0
5.6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
73.6
metabolite measurement
1
65.6
aspartate aminotransferase measurement
1
6.8
62.1
0
1.6
27.3
serum alanine aminotransferase measurement
0
5.6
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apurinic/apyrimidinic endodeoxyribonuclease 1
VGNC:8393
465200
Mouse
MGI:88042
11792
Rat
RGD:2126
79116
Dog
apurinic/apyrimidinic endodeoxyribonuclease 1
VGNC:54195
482558
Horse
apurinic/apyrimidinic endodeoxyribonuclease 1
VGNC:15404
100072588
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apurinic/apyrimidinic endodeoxyribonuclease 1
Mouse
Rat
Dog
apurinic/apyrimidinic endodeoxyribonuclease 1
Horse
apurinic/apyrimidinic endodeoxyribonuclease 1
Publication Statistics
PubMed Score 3048.70
PubMed score by year
PubTator Score 1272.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title