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Tbio
APELA
Apelin receptor early endogenous ligand

Protein Summary
Description
Endogenous ligand for the apelin receptor (APLNR) (PubMed:25639753, PubMed:28137936). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis (PubMed:25639753, PubMed:28137936). Drives internalization of APLNR. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating APLNR. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Plays a role in placental vascular development; promotes placental trophoblast invasion and spiral artery remodeling ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000507152
  • ENSP00000484618
  • ENSG00000248329
  • ENST00000510062
  • ENSP00000478306
  • ENST00000515275
  • ENSP00000480045

Symbol
  • ELA
  • TDL
  • ELA
  • tdl
  • Ende
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.7
kinase perturbation
0.21
gene perturbation
0.13
biological process
0
biological term
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.8   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.8   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
SCARF2
Tbio
Novelty:  0.08833851
Score:  0.914
Data Source:  STRINGDB
ZBP1
Tbio
Novelty:  0.01316413
Score:  0.679
Data Source:  STRINGDB
SH3GL1
Tbio
Novelty:  0.02379336
Score:  0.675
Data Source:  STRINGDB
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
Score:  0.669
Data Source:  STRINGDB
EPX
Tchem
Family:  Enzyme
Novelty:  0.00339273
Score:  0.669
Data Source:  STRINGDB
PLIN1
Tbio
Novelty:  0.00200378
Score:  0.669
Data Source:  STRINGDB
TOR3A
Tbio
Novelty:  0.11588309
Score:  0.589
Data Source:  STRINGDB
GLI1
Tchem
Family:  TF
Novelty:  0.00077281
Score:  0.577
Data Source:  STRINGDB
EDA
Tbio
Novelty:  0.00352464
Score:  0.557
Data Source:  STRINGDB
SLC6A3
Tclin
Family:  Transporter
Novelty:  0.00017601
Score:  0.549
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 112.80
PubMed score by year
PubTator Score 35.17
PubTator score by year
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Related Publications
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PMID
Year
Title