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Tbio
APC2
Adenomatous polyposis coli protein 2

Protein Summary
Description
Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329). This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233607
  • ENSP00000233607
  • ENSG00000115266
  • ENST00000535453
  • ENSP00000442954

Symbol
  • APCL
  • APCL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
cellular component
0.77
gene perturbation
0.7
cell line
0.66
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.06   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.06   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.987
Data Source:  STRINGDB
AXIN2
Tchem
Novelty:  0.00273189
Score:  0.982
Data Source:  STRINGDB
AXIN1
Tbio
Novelty:  0.00175842
Score:  0.98
Data Source:  STRINGDB
GSK3B
Tclin
Family:  Kinase
Novelty:  0.00095115
Score:  0.922
Data Source:  STRINGDB
JUP
Tbio
Novelty:  0.0081803
Score:  0.882
Data Source:  STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.872
Data Source:  STRINGDB
ARHGEF4
Tbio
Novelty:  0.01722153
Score:  0.865
Data Source:  STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.865
Data Source:  STRINGDB
DVL3
Tbio
Novelty:  0.01606014
Score:  0.865
Data Source:  STRINGDB
MAPRE3
Tbio
Novelty:  0.00454315
Score:  0.848
Data Source:  STRINGDB
Pathways (20)
Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Gastric cancer
KEGG
Cushing syndrome
KEGG
Breast cancer
KEGG
Regulation of actin cytoskeleton
KEGG
Signaling pathways regulating pluripotency of stem cells
Name
Explore in Pharos
Explore in Source
Gastric cancer
Cushing syndrome
Breast cancer
Regulation of actin cytoskeleton
Signaling pathways regulating pluripotency of stem cells
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
13.5
hematocrit
1
1
1
13.5
pulse pressure measurement
1
1
1
12.6
Urinary retention
1
1
0
7.8
3.7
response to radiation
1
1
0
7.8
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
13.5
hematocrit
1
13.5
pulse pressure measurement
1
12.6
Urinary retention
0
7.8
3.7
response to radiation
0
7.8
3.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
APC2, WNT signaling pathway regulator
707345
Mouse
MGI:1346052
23805
Rat
RGD:1308256
299611
Dog
APC2, WNT signaling pathway regulator
VGNC:54573
485084
Cow
APC2, WNT signaling pathway regulator
VGNC:26006
526572
Species
Name
OMA
EggNOG
Inparanoid
Macaque
APC2, WNT signaling pathway regulator
Mouse
Rat
Dog
APC2, WNT signaling pathway regulator
Cow
APC2, WNT signaling pathway regulator
Publication Statistics
PubMed Score 55.06
PubMed score by year
PubTator Score 76.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title