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Tbio
APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

Protein Summary
Description
May modulate the internalization of amyloid-beta precursor protein. The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354402
  • ENSP00000346378
  • ENSG00000113108
  • ENST00000356738
  • ENSP00000349177
  • ENST00000357560
  • ENSP00000350171
  • ENST00000412920
  • ENSP00000402591
  • ENST00000467078
  • ENSP00000422718
  • ENST00000509914
  • ENSP00000426107

Symbol
  • FE65L2
  • SRA
  • FE65L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
cell type or tissue
0.73
transcription factor binding site profile
0.73
virus perturbation
0.68
small molecule perturbation
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.11   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.11   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
RHOBTB1
Tbio
Novelty:  0.02152609
p_int:  1
Score:  0.625
Data Source:  BioPlex,STRINGDB
RHOBTB2
Tbio
Novelty:  0.00734789
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.218
Data Source:  BioPlex,STRINGDB
APLP1
Tbio
Novelty:  0.01063681
p_int:  0.999980979
p_ni:  0.000018897
p_wrong:  1.25e-7
Score:  0.699
Data Source:  BioPlex,STRINGDB
APLP2
Tbio
Novelty:  0.0082936
p_int:  0.999721246
p_ni:  0.000278754
Score:  0.715
Data Source:  BioPlex,STRINGDB
APP
Tchem
Novelty:  0.00008964
p_int:  0.99957742
p_ni:  0.00042258
Score:  0.681
Data Source:  BioPlex,STRINGDB
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.9995568
p_ni:  0.0004432
Score:  0.759
Data Source:  BioPlex,STRINGDB
COPS7B
Tbio
Novelty:  0.63421506
p_int:  0.995364963
p_ni:  0.004635037
Score:  0.764
Data Source:  BioPlex,STRINGDB
COPS3
Tbio
Novelty:  0.04664225
p_int:  0.994030001
p_ni:  0.005969999
Score:  0.708
Data Source:  BioPlex,STRINGDB
COPS7A
Tbio
Novelty:  0.02159233
p_int:  0.992806126
p_ni:  0.007193874
Score:  0.691
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
p_int:  0.991976905
p_ni:  0.008023095
Score:  0.708
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
0
6.4
42.3
household income
1
1
1
24.5
monocyte count
1
1
1
13.8
inflammatory biomarker measurement
1
1
0
125.7
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
6.4
42.3
household income
1
24.5
monocyte count
1
13.8
inflammatory biomarker measurement
0
125.7
6.1
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amyloid beta precursor protein binding family B member 3
VGNC:6835
462116
Macaque
amyloid beta precursor protein binding family B member 3
698296
Mouse
MGI:1344414
24068
Rat
RGD:620853
117026
Dog
amyloid beta precursor protein binding family B member 3
VGNC:49761
606955
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amyloid beta precursor protein binding family B member 3
Macaque
amyloid beta precursor protein binding family B member 3
Mouse
Rat
Dog
amyloid beta precursor protein binding family B member 3
Publication Statistics
PubMed Score 6.11
PubMed score by year
PubTator Score 8.94
PubTator score by year
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Related Publications
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PMID
Year
Title