You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
APBB2
Amyloid-beta A4 precursor protein-binding family B member 2

Protein Summary
Description
May modulate the internalization of amyloid-beta precursor protein. The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295974
  • ENSP00000295974
  • ENSG00000163697
  • ENST00000502841
  • ENSP00000425802
  • ENST00000504305
  • ENSP00000423765
  • ENST00000508593
  • ENSP00000427211
  • ENST00000513140
  • ENSP00000426018
  • ENST00000543538
  • ENSP00000439357

Symbol
  • FE65L
  • FE65L1
  • FE65L
  • FE65L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.95
transcription factor binding site profile
0.93
microRNA
0.92
PubMedID
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.82   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.82   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
APLP1
Tbio
Novelty:  0.01063681
p_int:  0.999999998
p_ni:  2e-9
Score:  0.963
Data Source:  BioPlex,STRINGDB
SYDE2
Tdark
Family:  Enzyme
Novelty:  1.77288781
p_int:  0.999999389
p_ni:  5.26e-7
p_wrong:  8.6e-8
Score:  0.353
Data Source:  BioPlex,STRINGDB
APLP2
Tbio
Novelty:  0.0082936
p_int:  0.999996273
p_ni:  0.000003727
Score:  0.978
Data Source:  BioPlex,STRINGDB
APP
Tchem
Novelty:  0.00008964
p_int:  0.999986814
p_ni:  0.000013186
Score:  0.958
Data Source:  BioPlex,STRINGDB
ATP7A
Tbio
Family:  Enzyme
Novelty:  0.00064155
p_int:  0.999974884
p_ni:  0.000025099
p_wrong:  1.7e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
WISP3
Tbio
Novelty:  0.008264
p_int:  0.999947157
p_ni:  0.000052843
Score:  0.189
Data Source:  BioPlex,STRINGDB
AKAP1
Tbio
Family:  Epigenetic
Novelty:  0.00437217
p_int:  0.999913204
p_ni:  0.000086796
Score:  0.198
Data Source:  BioPlex,STRINGDB
OSBPL2
Tbio
Novelty:  0.03946704
p_int:  0.99987232
p_ni:  0.000127671
p_wrong:  8e-9
Score:  0.198
Data Source:  BioPlex,STRINGDB
QTRT1
Tbio
Family:  Enzyme
Novelty:  0.04387363
p_int:  0.999791913
p_ni:  0.000208065
p_wrong:  2.2e-8
Score:  0.555
Data Source:  BioPlex,STRINGDB
WDR41
Tbio
Novelty:  0.20400077
p_int:  0.999010845
p_ni:  0.000895245
p_wrong:  0.000093911
Score:  0.198
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
1
1
62.8
1
1
0
1.2
57.3
mathematical ability
1
1
1
26.6
monocyte percentage of leukocytes
1
1
1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
62.8
0
1.2
57.3
mathematical ability
1
26.6
monocyte percentage of leukocytes
1
5.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amyloid beta precursor protein binding family B member 2
VGNC:7043
461184
Macaque
amyloid beta precursor protein binding family B member 2
701342
Mouse
MGI:108405
11787
Dog
amyloid beta precursor protein binding family B member 2
VGNC:37979
488831
Horse
amyloid beta precursor protein binding family B member 2
VGNC:15400
100054890
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amyloid beta precursor protein binding family B member 2
Macaque
amyloid beta precursor protein binding family B member 2
Mouse
Dog
amyloid beta precursor protein binding family B member 2
Horse
amyloid beta precursor protein binding family B member 2
Publication Statistics
PubMed Score 18.82
PubMed score by year
PubTator Score 12.01
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title