Tbio APBB1 Amyloid-beta A4 precursor protein-binding family B member 1

Protein Summary

Description

Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• O00213
• A1E379
• A6NH82
• A6NL69
• B7Z1J5
• B7Z1J6
• B7Z2Y0
• D3DQT2
• Q7Z324
• Q96A93
• V9GYK0
• V9GYT4

Gene Name

• APBB1

Ensembl ID

• ENST00000299402
• ENSP00000299402
• ENSG00000166313
• ENST00000311051
• ENSP00000311912
• ENST00000530885
• ENSP00000433338
• ENST00000608394
• ENSP00000476442
• ENST00000608645
• ENSP00000476646
• ENST00000608655
• ENSP00000476846
• ENST00000608704
• ENSP00000476871
• ENST00000609331
• ENSP00000477069
• ENST00000609360
• ENSP00000477213

Symbol

• FE65
• RIR
• RIR
• FE65
• MGC:9072

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
disease perturbation	0.87
histone modification site profile	0.7
cellular component	0.68
hub protein	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.42   (req: < 5)

Gene RIFs: 51   (req: <= 3)

Antibodies: 355   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.42   (req: >= 5)

Gene RIFs: 51   (req: > 3)

Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0