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Tbio
APBB1
Amyloid-beta A4 precursor protein-binding family B member 1

Protein Summary
Description
Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). The protein encoded ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299402
  • ENSP00000299402
  • ENSG00000166313
  • ENST00000311051
  • ENSP00000311912
  • ENST00000530885
  • ENSP00000433338
  • ENST00000608394
  • ENSP00000476442
  • ENST00000608645
  • ENSP00000476646
  • ENST00000608655
  • ENSP00000476846
  • ENST00000608704
  • ENSP00000476871
  • ENST00000609331
  • ENSP00000477069
  • ENST00000609360
  • ENSP00000477213

Symbol
  • FE65
  • RIR
  • RIR
  • FE65
  • MGC:9072
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
disease perturbation
0.87
histone modification site profile
0.7
cellular component
0.68
hub protein
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.42   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.42   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0