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Tchem
APAF1
Apoptotic protease-activating factor 1

Protein Summary
Description
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333991
  • ENSP00000334558
  • ENSG00000120868
  • ENST00000357310
  • ENSP00000349862
  • ENST00000359972
  • ENSP00000353059
  • ENST00000547045
  • ENSP00000449791
  • ENST00000550527
  • ENSP00000448449
  • ENST00000551964
  • ENSP00000448165
  • ENST00000552268
  • ENSP00000448826

Symbol
  • KIAA0413
  • CED4
  • APAF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.95
histone modification site profile
0.88
transcription factor perturbation
0.84
chemical
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 901.83   (req: < 5)
Gene RIFs: 105   (req: <= 3)
Antibodies: 670   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 901.83   (req: >= 5)
Gene RIFs: 105   (req: > 3)
Antibodies: 670   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0