AP5Z1
AP-5 complex subunit zeta-1
Protein Summary
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011]
- ENST00000348624
- ENSP00000297562
- ENSG00000242802
- ENST00000648925
- ENSP00000496830
- ENST00000649063
- ENSP00000497815
- KIAA0415
- SPG48
- zeta
- SPG48
- KIAA0415
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.92 | ||
transcription factor perturbation | 0.74 | ||
transcription factor binding site profile | 0.72 | ||
tissue sample | 0.64 | ||
cell line | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.24 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 67 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.24 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 67 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (80)
SPG11
Novelty: 0.00697875
p_int: 0.999999915
p_ni: 8.4e-8
p_wrong: 1e-9
Score: 0.946
Data Source: BioPlex,STRINGDB
SAYSD1
Novelty: 0.62764863
p_int: 0.999479099
p_ni: 0.000520879
p_wrong: 2.2e-8
Data Source: BioPlex
LYPD4
Novelty: 0.00381728
p_int: 0.886524656
p_ni: 0.00273263
p_wrong: 0.110742715
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (9)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mosquito bite reaction itch intensity measurement | 1 | 1 | 1 | 24.5 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 21.5 | |||||
parental longevity | 1 | 1 | 1 | 17.8 | |||||
electrocardiography | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mosquito bite reaction itch intensity measurement | 1 | 24.5 | |||||
apolipoprotein A 1 measurement | 1 | 21.5 | |||||
parental longevity | 1 | 17.8 | |||||
electrocardiography | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | adaptor related protein complex 5 subunit zeta 1 | VGNC:7213 | 472273 | |||||
Macaque | adaptor related protein complex 5 zeta 1 subunit | 715686 | ||||||
Mouse | MGI:1924908 | 231855 | ||||||
Dog | adaptor related protein complex 5 subunit zeta 1 | VGNC:37973 | 609375 | |||||
Horse | adaptor related protein complex 5 subunit zeta 1 | VGNC:15394 | 100060677 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | adaptor related protein complex 5 subunit zeta 1 | |||||
Macaque | adaptor related protein complex 5 zeta 1 subunit | |||||
Mouse | ||||||
Dog | adaptor related protein complex 5 subunit zeta 1 | |||||
Horse | adaptor related protein complex 5 subunit zeta 1 | |||||
Publication Statistics
PubMed Score 7.24
PubMed score by year
PubTator Score 7.09
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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