Tdark AP5S1 AP-5 complex subunit sigma-1

Protein Summary

Description

As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair.

Uniprot Accession IDs

• Q9NUS5
• B3KSD0
• D3DVY7

Gene Name

• AP5S1

Ensembl ID

• ENST00000246041
• ENSP00000246041
• ENSG00000125843
• ENST00000379567
• ENSP00000368886
• ENST00000615891
• ENSP00000481750

Symbol

• C20orf29
• C20orf29

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.94
cell type or tissue	0.79
histone modification site profile	0.75
small molecule perturbation	0.69
cellular component	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.49   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 9   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.49   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0