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Tdark
AP4E1
AP-4 complex subunit epsilon-1

Protein Summary
Description
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261842
  • ENSP00000261842
  • ENSG00000081014
  • ENST00000560508
  • ENSP00000452976

Symbol
  • CPSQ4
  • SPG51
  • STUT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.87
virus perturbation
0.76
protein domain
0.73
microRNA
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.67   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.67   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (148)
SUV39H2
Tchem
Family:  Epigenetic
Novelty:  0.02232167
p_int:  1
Score:  0.63
Data Source:  BioPlex,STRINGDB
TEPSIN
Tdark
Novelty:  0.48775142
p_int:  0.999999994
p_ni:  5e-9
Score:  0.838
Data Source:  BioPlex,STRINGDB
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.999999956
p_ni:  4.3e-8
p_wrong:  1e-9
Data Source:  BioPlex
AP4B1
Tbio
Novelty:  0.08255831
p_int:  0.999999784
p_ni:  5.4e-8
p_wrong:  1.62e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
AP4S1
Tdark
Novelty:  0.1142558
Score:  0.997
Data Source:  Reactome,STRINGDB
AP4M1
Tbio
Novelty:  0.00142961
Score:  0.994
Data Source:  Reactome,STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.983
Data Source:  STRINGDB
IGF2R
Tchem
Novelty:  0.00138374
Score:  0.974
Data Source:  STRINGDB
AP3B1
Tbio
Novelty:  0.03117931
Score:  0.971
Data Source:  STRINGDB
AP1B1
Tbio
Novelty:  0.03370208
Score:  0.957
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Lysosome Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Golgi Associated Vesicle Biogenesis
Lysosome Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
70.9
self reported educational attainment
1
1
1
42.3
1
1
1
36.9
neutrophil count
1
1
1
31.2
potassium measurement
1
1
1
24.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
70.9
self reported educational attainment
1
42.3
1
36.9
neutrophil count
1
31.2
potassium measurement
1
24.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 4 subunit epsilon 1
VGNC:6443
453432
Macaque
adaptor related protein complex 4 epsilon 1 subunit
693444
Mouse
MGI:1336993
108011
Rat
RGD:1562199
311404
Dog
adaptor related protein complex 4 subunit epsilon 1
VGNC:37969
478304
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 4 subunit epsilon 1
Macaque
adaptor related protein complex 4 epsilon 1 subunit
Mouse
Rat
Dog
adaptor related protein complex 4 subunit epsilon 1
Publication Statistics
PubMed Score 11.67
PubMed score by year
PubTator Score 3.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title