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Tbio
AP3M2
AP-3 complex subunit mu-2

Protein Summary
Description
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000174653
  • ENSP00000174653
  • ENSG00000070718
  • ENST00000396926
  • ENSP00000380132
  • ENST00000518421
  • ENSP00000428787
  • ENST00000530375
  • ENSP00000431918

Symbol
  • P47B
  • AP47B
  • CLA20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor binding site profile
0.86
protein domain
0.85
virus perturbation
0.83
histone modification site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.41   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.41   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
AP3S1
Tbio
Novelty:  0.12425009
p_int:  1
Score:  0.977
Data Source:  BioPlex,STRINGDB
AP3M1
Tbio
Novelty:  0.5036622
p_int:  0.999999954
p_ni:  4.6e-8
Score:  0.964
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999999901
p_ni:  9.9e-8
Data Source:  BioPlex
AP3B1
Tbio
Novelty:  0.03117931
p_int:  0.999905302
p_ni:  0.000094698
Score:  0.986
Data Source:  BioPlex,STRINGDB
AP3S2
Tdark
Novelty:  0.25186243
p_int:  0.999860065
p_ni:  0.000049157
p_wrong:  0.000090778
Score:  0.979
Data Source:  BioPlex,STRINGDB
EDA
Tbio
Novelty:  0.00352464
p_int:  0.999697945
p_ni:  0.000301916
p_wrong:  1.39e-7
Score:  0.307
Data Source:  BioPlex,STRINGDB
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.999310983
p_ni:  0.000689017
Score:  0.237
Data Source:  BioPlex,STRINGDB
TCEAL9
Tdark
Novelty:  0.3050647
p_int:  0.999216276
p_ni:  0.000782859
p_wrong:  8.65e-7
Data Source:  BioPlex
AP3D1
Tbio
Novelty:  0.04425592
p_int:  0.994317857
p_ni:  0.005682143
Score:  0.994
Data Source:  BioPlex,STRINGDB
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.977687428
p_ni:  0.022305275
p_wrong:  0.000007298
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
60
tissue plasminogen activator measurement
1
1
1
48
1
1
1
46.5
1
1
0
1.9
29.6
serum non-albumin protein measurement
1
1
1
25.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
60
tissue plasminogen activator measurement
1
48
1
46.5
0
1.9
29.6
serum non-albumin protein measurement
1
25.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 3 subunit mu 2
VGNC:6559
472747
Macaque
adaptor related protein complex 3 mu 2 subunit
100430586
Mouse
MGI:1929214
64933
Rat
RGD:70969
140667
Dog
adaptor related protein complex 3 subunit mu 2
VGNC:51786
482841
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 3 subunit mu 2
Macaque
adaptor related protein complex 3 mu 2 subunit
Mouse
Rat
Dog
adaptor related protein complex 3 subunit mu 2
Publication Statistics
PubMed Score 5.41
PubMed score by year
PubTator Score 1.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title