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Tbio
AP2S1
AP-2 complex subunit sigma

Protein Summary
Description
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to pl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263270
  • ENSP00000263270
  • ENSG00000042753
  • ENST00000601649
  • ENSP00000470898

Symbol
  • AP17
  • CLAPS2
  • AP17
  • FBH3
  • HHC3
  • FBHOk
  • CLAPS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
interacting protein
0.9
co-expressed gene
0.82
disease perturbation
0.74
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.48   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.48   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (265)
AP2M1
Tbio
Novelty:  0.00769368
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
AAK1
Tchem
Family:  Kinase
Novelty:  0.02438961
p_int:  0.999999996
p_ni:  3e-9
Score:  0.986
Data Source:  BioPlex,STRINGDB
AAGAB
Tbio
Novelty:  0.0479209
p_int:  0.999999993
p_ni:  7e-9
Score:  0.572
Data Source:  BioPlex,STRINGDB
STON2
Tbio
Novelty:  0.02098671
p_int:  0.99999997
p_ni:  2.6e-8
p_wrong:  4e-9
Score:  0.965
Data Source:  BioPlex,STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
p_int:  0.999999813
p_ni:  1.85e-7
p_wrong:  2e-9
Score:  0.977
Data Source:  BioPlex,STRINGDB
EPS15
Tchem
Novelty:  0.00451447
p_int:  0.999999742
p_ni:  2.58e-7
Score:  0.975
Data Source:  BioPlex,STRINGDB
FCHO2
Tbio
Novelty:  0.12302279
p_int:  0.999999488
p_ni:  8.2e-8
p_wrong:  4.3e-7
Score:  0.953
Data Source:  BioPlex,STRINGDB
NECAP2
Tdark
Novelty:  0.4141034
p_int:  0.999999347
p_ni:  6.53e-7
Score:  0.983
Data Source:  BioPlex,STRINGDB
BMP2K
Tchem
Family:  Kinase
Novelty:  0.10145601
p_int:  0.999999196
p_ni:  8.04e-7
Score:  0.791
Data Source:  BioPlex,STRINGDB
CCDC32
Tdark
Novelty:  1.80929769
p_int:  0.999999066
p_ni:  9.34e-7
Score:  0.816
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (51)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Beta-catenin independent WNT signaling
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Beta-catenin independent WNT signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
31.4
sun exposure measurement
1
1
0
11.3
17.8
eye measurement
1
1
0
11.3
17.8
low density lipoprotein cholesterol measurement
1
1
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
31.4
sun exposure measurement
0
11.3
17.8
eye measurement
0
11.3
17.8
low density lipoprotein cholesterol measurement
1
2.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 2 subunit sigma 1
VGNC:6612
456156
Macaque
adaptor related protein complex 2 sigma 1 subunit
716911
Mouse
MGI:2141861
232910
Rat
RGD:620188
65046
Dog
adaptor related protein complex 2 subunit sigma 1
VGNC:37962
476427
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 2 subunit sigma 1
Macaque
adaptor related protein complex 2 sigma 1 subunit
Mouse
Rat
Dog
adaptor related protein complex 2 subunit sigma 1
Publication Statistics
PubMed Score 48.48
PubMed score by year
PubTator Score 20.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title