Tbio AP2S1 AP-2 complex subunit sigma

Protein Summary

Description

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis. One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• P53680
• B2R4Z4
• O75977
• Q6PK67

Gene Name

• AP2S1

Ensembl ID

• ENST00000263270
• ENSP00000263270
• ENSG00000042753
• ENST00000601649
• ENSP00000470898

Symbol

• AP17
• CLAPS2
• AP17
• FBH3
• HHC3
• FBHOk
• CLAPS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
interacting protein	0.9
co-expressed gene	0.82
disease perturbation	0.74
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Ap-2 Complex Subunit Sigma

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Ap-2 Complex Subunit Sigma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.48   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.48   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (265)

Explore Interacting Targets

1 – 10 of 265

• See Interactions on String-DB

AP2M1

Tbio

Novelty:  0.00769368

p_int:  1

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

AAK1

Tchem

Family:  Kinase

Novelty:  0.02438961

p_int:  0.999999996

p_ni:  3e-9

Score:  0.986

Data Source:  BioPlex,STRINGDB

AAGAB

Tbio

Novelty:  0.0479209

p_int:  0.999999993

p_ni:  7e-9

Score:  0.572

Data Source:  BioPlex,STRINGDB

STON2

Tbio

Novelty:  0.02098671

p_int:  0.99999997

p_ni:  2.6e-8

p_wrong:  4e-9

Score:  0.965

Data Source:  BioPlex,STRINGDB

ITSN1

Tbio

Novelty:  0.01327346

p_int:  0.999999813

p_ni:  1.85e-7

p_wrong:  2e-9

Score:  0.977

Data Source:  BioPlex,STRINGDB

EPS15

Tchem

Novelty:  0.00451447

p_int:  0.999999742

p_ni:  2.58e-7

Score:  0.975

Data Source:  BioPlex,STRINGDB

FCHO2

Tbio

Novelty:  0.12302279

p_int:  0.999999488

p_ni:  8.2e-8

p_wrong:  4.3e-7

Score:  0.953

Data Source:  BioPlex,STRINGDB

NECAP2

Tdark

Novelty:  0.4141034

p_int:  0.999999347

p_ni:  6.53e-7

Score:  0.983

Data Source:  BioPlex,STRINGDB

BMP2K

Tchem

Family:  Kinase

Novelty:  0.10145601

p_int:  0.999999196

p_ni:  8.04e-7

Score:  0.791

Data Source:  BioPlex,STRINGDB

CCDC32

Tdark

Novelty:  1.80929769

p_int:  0.999999066

p_ni:  9.34e-7

Score:  0.816

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (51)

Reactome (42)

KEGG (4)

PathwayCommons (1)

WikiPathways (4)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Axon guidance	533 targets	R-HSA-422475
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (20)

Functions (2)

Components (7)

Processes (11)

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1 – 2 of 2

GO Term	Evidence	Assigned by
protein transporter activity	Non-traceable Author Statement (NAS)	UniProtKB
transporter activity	Non-traceable Author Statement (NAS)	ProtInc

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
smoking status measurement	EFO_0006527	1	1	1		31.4
sun exposure measurement	EFO_0010729	1	1	0	11.3	17.8
eye measurement	EFO_0004731	1	1	0	11.3	17.8
low density lipoprotein cholesterol measurement	EFO_0004611	1	1	1		2.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
smoking status measurement	EFO_0006527	1		31.4
sun exposure measurement	EFO_0010729	0	11.3	17.8
eye measurement	EFO_0004731	0	11.3	17.8
low density lipoprotein cholesterol measurement	EFO_0004611	1		2.2

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Coated pit
Complete proteome
Disease mutation
Endocytosis
Membrane
Phosphoprotein
Protein transport
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
eye measurement
low density lipoprotein cholesterol measurement
smoking status measurement
sun exposure measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
nervous system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	adaptor related protein complex 2 subunit sigma 1	VGNC:6612	456156
Macaque	adaptor related protein complex 2 sigma 1 subunit		716911
Mouse	adaptor-related protein complex 2, sigma 1 subunit	MGI:2141861	232910
Rat	adaptor related protein complex 2 subunit sigma 1	RGD:620188	65046
Dog	adaptor related protein complex 2 subunit sigma 1	VGNC:37962	476427

Species	Name	OMA	EggNOG	Inparanoid
Chimp	adaptor related protein complex 2 subunit sigma 1
Macaque	adaptor related protein complex 2 sigma 1 subunit
Mouse	adaptor-related protein complex 2, sigma 1 subunit
Rat	adaptor related protein complex 2 subunit sigma 1
Dog	adaptor related protein complex 2 subunit sigma 1

Publication Statistics

PubMed Score 48.48

PubMed score by year

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PubTator Score 20.54

PubTator score by year

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Related Publications

Text Mined References (26)

GeneRif Annotations (8)

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PMID	Year	Title