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Tbio
AP2M1
AP-2 complex subunit mu

Protein Summary
Description
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to pl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292807
  • ENSP00000292807
  • ENSG00000161203
  • ENST00000382456
  • ENSP00000371894
  • ENST00000439647
  • ENSP00000409081

Symbol
  • CLAPM1
  • KIAA0109
  • mu2
  • AP50
  • CLAPM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.97
co-expressed gene
0.94
drug perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.98   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 489   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.98   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 489   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (352)
AP2S1
Tbio
Novelty:  0.01931502
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NECAP2
Tdark
Novelty:  0.4141034
p_int:  0.999999999
p_ni:  1e-9
Score:  0.959
Data Source:  BioPlex,STRINGDB
AAK1
Tchem
Family:  Kinase
Novelty:  0.02438961
p_int:  0.999999998
p_ni:  2e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
ITSN2
Tbio
Novelty:  0.03036854
p_int:  0.999999995
p_ni:  2e-9
p_wrong:  3e-9
Score:  0.957
Data Source:  BioPlex,STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
p_int:  0.999999994
p_ni:  4e-9
p_wrong:  1e-9
Score:  0.966
Data Source:  BioPlex,STRINGDB
REPS1
Tbio
Novelty:  0.08952347
p_int:  0.999999993
p_ni:  7e-9
Score:  0.981
Data Source:  BioPlex,STRINGDB
CALCOCO1
Tbio
Novelty:  0.17497928
p_int:  0.999999951
p_ni:  4.9e-8
Data Source:  BioPlex
EPS15
Tchem
Novelty:  0.00451447
p_int:  0.999999886
p_ni:  1.14e-7
Score:  0.97
Data Source:  BioPlex,STRINGDB
STON2
Tbio
Novelty:  0.02098671
p_int:  0.999999867
p_ni:  1.33e-7
Score:  0.966
Data Source:  BioPlex,STRINGDB
KIF13A
Tbio
Novelty:  0.04988003
p_int:  0.999999846
p_ni:  9.7e-8
p_wrong:  5.7e-8
Score:  0.248
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (57)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 47
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Beta-catenin independent WNT signaling
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Beta-catenin independent WNT signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1
1
74.8
mathematical ability
4
3
4
71.2
body mass index
2
2
2
67.8
mean corpuscular hemoglobin concentration
1
1
1
49.5
high density lipoprotein cholesterol measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
74.8
mathematical ability
4
71.2
body mass index
2
67.8
mean corpuscular hemoglobin concentration
1
49.5
high density lipoprotein cholesterol measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 2 subunit mu 1
VGNC:7027
736431
Macaque
adaptor related protein complex 2 mu 1 subunit
703554
Mouse
MGI:1298405
11773
Rat
RGD:620135
116563
Dog
adaptor related protein complex 2 subunit mu 1
VGNC:37961
607139
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 2 subunit mu 1
Macaque
adaptor related protein complex 2 mu 1 subunit
Mouse
Rat
Dog
adaptor related protein complex 2 subunit mu 1
Publication Statistics
PubMed Score 130.98
PubMed score by year
PubTator Score 39.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title