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Tbio
AP2B1
AP-2 complex subunit beta

Protein Summary
Description
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to pl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610402
  • ENSP00000483185
  • ENSG00000006125
  • ENST00000618940
  • ENSP00000482835
  • ENST00000621914
  • ENSP00000482315

Symbol
  • ADTB2
  • CLAPB1
  • ADTB2
  • AP105B
  • CLAPB1
  • AP2-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.96
transcription factor binding site profile
0.88
microRNA
0.86
hub protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.16   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.16   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (308)
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999902411
p_ni:  0.000097589
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
AP2S1
Tbio
Novelty:  0.01931502
p_int:  0.998420133
p_ni:  0.001579867
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.997693583
p_ni:  0.002306416
p_wrong:  1e-9
Score:  0.955
Data Source:  BioPlex,STRINGDB
AP1S2
Tbio
Novelty:  0.01413503
p_int:  0.996729689
p_ni:  0.003270311
Score:  0.982
Data Source:  BioPlex,STRINGDB
NECAP2
Tdark
Novelty:  0.4141034
p_int:  0.996686652
p_ni:  0.003313348
Score:  0.983
Data Source:  BioPlex,STRINGDB
AMPH
Tbio
Novelty:  0.00201043
p_int:  0.993414653
p_ni:  0.006585347
Score:  0.986
Data Source:  BioPlex,STRINGDB
AP1M2
Tbio
Novelty:  0.02984354
p_int:  0.98288437
p_ni:  0.01711563
Score:  0.984
Data Source:  BioPlex,STRINGDB
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
p_int:  0.974612481
p_ni:  0.025387519
Score:  0.965
Data Source:  BioPlex,STRINGDB
MEA1
Tbio
Novelty:  0.04292367
p_int:  0.959752399
p_ni:  0.040247601
Data Source:  BioPlex
AP1S3
Tbio
Novelty:  0.14425094
p_int:  0.95327512
p_ni:  0.04672488
Score:  0.405
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (71)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Beta-catenin independent WNT signaling
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Beta-catenin independent WNT signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
10
23
99.5
mean platelet volume
4
8
9
99.3
platelet count
5
8
9
3.6
99.2
reticulocyte measurement
3
7
12
99.2
platelet crit
2
3
3
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
23
99.5
mean platelet volume
9
99.3
platelet count
9
3.6
99.2
reticulocyte measurement
12
99.2
platelet crit
3
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
adaptor related protein complex 2 beta 1 subunit
100429215
Mouse
MGI:1919020
71770
Rat
RGD:71048
140670
Dog
adaptor related protein complex 2 subunit beta 1
VGNC:37960
480605
Horse
adaptor related protein complex 2 subunit beta 1
VGNC:15379
100058050
Species
Name
OMA
EggNOG
Inparanoid
Macaque
adaptor related protein complex 2 beta 1 subunit
Mouse
Rat
Dog
adaptor related protein complex 2 subunit beta 1
Horse
adaptor related protein complex 2 subunit beta 1
Publication Statistics
PubMed Score 101.16
PubMed score by year
PubTator Score 24.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title