Tbio AP1S2 AP-1 complex subunit sigma-2

Protein Summary

Description

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• P56377
• B4DSU4
• O95326
• Q9H2N6

Gene Name

• AP1S2

Ensembl ID

• ENST00000329235
• ENSP00000328789
• ENSG00000182287

Symbol

• PGS
• DC22
• MRX59
• MRXS5
• MRXSF
• MRXS21
• SIGMA1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
histone modification site profile	0.88
PubMedID	0.77
cellular component	0.76
virus perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Ap-1 Complex Subunit Sigma-2

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Ap-1 Complex Subunit Sigma-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.78   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.78   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0