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Tbio
AP1S1
AP-1 complex subunit sigma-1A

Protein Summary
Description
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337619
  • ENSP00000336666
  • ENSG00000106367
  • ENST00000443943
  • ENSP00000410780

Symbol
  • AP19
  • CLAPS1
  • AP19
  • EKV3
  • CLAPS1
  • MEDNIK
  • SIGMA1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
cellular component
0.85
interacting protein
0.72
small molecule perturbation
0.72
tissue sample
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.47   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.47   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (185)
AP1M2
Tbio
Novelty:  0.02984354
p_int:  0.999999969
p_ni:  3e-8
p_wrong:  1e-9
Score:  0.977
Data Source:  BioPlex,Reactome,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999994839
p_ni:  0.000001281
p_wrong:  0.000003879
Score:  0.923
Data Source:  BioPlex,STRINGDB
AP1M1
Tbio
Novelty:  0.029282
Score:  0.999
Data Source:  Reactome,STRINGDB
AP1B1
Tbio
Novelty:  0.03370208
Score:  0.999
Data Source:  Reactome,STRINGDB
AP1G1
Tbio
Novelty:  0.03754132
Score:  0.999
Data Source:  Reactome,STRINGDB
AP1G2
Tbio
Novelty:  0.17203425
Score:  0.986
Data Source:  STRINGDB
AP2B1
Tbio
Novelty:  0.00921093
Score:  0.986
Data Source:  STRINGDB
AP4B1
Tbio
Novelty:  0.08255831
Score:  0.949
Data Source:  STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
Score:  0.946
Data Source:  STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.945
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Disease
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Disease
Golgi Associated Vesicle Biogenesis
HIV Infection
Host Interactions of HIV factors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
81.5
lymphocyte count
1
1
1
53.3
body mass index
1
1
1
44.2
plasminogen activator inhibitor 1 measurement
1
1
1
38.7
apolipoprotein A 1 measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
81.5
lymphocyte count
1
53.3
body mass index
1
44.2
plasminogen activator inhibitor 1 measurement
1
38.7
apolipoprotein A 1 measurement
1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 1 subunit sigma 1
VGNC:7211
740971
Mouse
MGI:1098244
11769
Rat
RGD:1305911
360785
Dog
adaptor related protein complex 1 subunit sigma 1
VGNC:37956
100688000
Horse
adaptor related protein complex 1 subunit sigma 1
VGNC:51103
100060194
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 1 subunit sigma 1
Mouse
Rat
Dog
adaptor related protein complex 1 subunit sigma 1
Horse
adaptor related protein complex 1 subunit sigma 1
Publication Statistics
PubMed Score 56.47
PubMed score by year
PubTator Score 12.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title