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Tbio
AP1M2
AP-1 complex subunit mu-2

Protein Summary
Description
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250244
  • ENSP00000250244
  • ENSG00000129354
  • ENST00000590923
  • ENSP00000465685

Symbol
  • mu2
  • MU1B
  • MU-1B
  • HSMU1B
  • AP1-mu2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cellular component
0.79
interacting protein
0.75
PubMedID
0.72
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.97   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.97   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
AP1S2
Tbio
Novelty:  0.01413503
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
AP1S1
Tbio
Novelty:  0.01740202
p_int:  0.999999969
p_ni:  3e-8
p_wrong:  1e-9
Score:  0.977
Data Source:  BioPlex,Reactome,STRINGDB
AP1G2
Tbio
Novelty:  0.17203425
p_int:  0.999999498
p_ni:  5.02e-7
Score:  0.977
Data Source:  BioPlex,STRINGDB
AP1B1
Tbio
Novelty:  0.03370208
p_int:  0.999993878
p_ni:  0.000006122
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
AP1G1
Tbio
Novelty:  0.03754132
p_int:  0.999985763
p_ni:  0.000014237
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
TMF1
Tbio
Novelty:  0.02543575
p_int:  0.99735729
p_ni:  0.000559424
p_wrong:  0.002083287
Score:  0.232
Data Source:  BioPlex,STRINGDB
AP1S3
Tbio
Novelty:  0.14425094
p_int:  0.994238773
p_ni:  6.9e-8
p_wrong:  0.005761157
Score:  0.975
Data Source:  BioPlex,Reactome,STRINGDB
AP2B1
Tbio
Novelty:  0.00921093
p_int:  0.98288437
p_ni:  0.01711563
Score:  0.984
Data Source:  BioPlex,STRINGDB
AFTPH
Tbio
Novelty:  0.21887849
p_int:  0.97908955
p_ni:  0.00090943
p_wrong:  0.020001019
Score:  0.889
Data Source:  BioPlex,STRINGDB
HEATR5B
Tdark
Novelty:  3.21111035
p_int:  0.966806194
p_ni:  0.032632846
p_wrong:  0.00056096
Score:  0.818
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Disease
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Disease
Golgi Associated Vesicle Biogenesis
HIV Infection
Host Interactions of HIV factors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
1
1.1
96.1
low density lipoprotein cholesterol measurement
3
8
9
95.5
red blood cell distribution width
4
5
6
94
body height
2
2
2
93.6
total cholesterol measurement
2
7
8
89.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
96.1
low density lipoprotein cholesterol measurement
9
95.5
red blood cell distribution width
6
94
body height
2
93.6
total cholesterol measurement
8
89.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 1 subunit mu 2
VGNC:6611
455710
Mouse
MGI:1336974
11768
Rat
RGD:1561490
367038
Dog
adaptor related protein complex 1 subunit mu 2
VGNC:37955
611211
Horse
adaptor related protein complex 1 subunit mu 2
VGNC:15376
100055078
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 1 subunit mu 2
Mouse
Rat
Dog
adaptor related protein complex 1 subunit mu 2
Horse
adaptor related protein complex 1 subunit mu 2
Publication Statistics
PubMed Score 38.97
PubMed score by year
PubTator Score 144.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title