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Tbio
AP1G2
AP-1 complex subunit gamma-like 2

Protein Summary
Description
May function in protein sorting in late endosomes or multivesucular bodies (MVBs). (Microbial infection) Involved in MVB-assisted maturation of hepatitis B virus (HBV). Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308724
  • ENSP00000312442
  • ENSG00000213983
  • ENST00000397120
  • ENSP00000380309

Symbol
  • G2AD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cellular component
0.79
gene perturbation
0.76
transcription factor
0.74
cell type or tissue
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.17   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.17   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
AP1S2
Tbio
Novelty:  0.01413503
p_int:  0.999999954
p_ni:  4.6e-8
Score:  0.992
Data Source:  BioPlex,STRINGDB
AP1M2
Tbio
Novelty:  0.02984354
p_int:  0.999999498
p_ni:  5.02e-7
Score:  0.977
Data Source:  BioPlex,STRINGDB
AP1S3
Tbio
Novelty:  0.14425094
p_int:  0.999995206
p_ni:  0.000004793
Score:  0.919
Data Source:  BioPlex,STRINGDB
SYNRG
Tdark
Novelty:  0.03621564
p_int:  0.999969914
p_ni:  0.000030078
p_wrong:  8e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.999625724
p_ni:  0.000374273
p_wrong:  2e-9
Data Source:  BioPlex
RBM14
Tbio
Novelty:  0.01286049
p_int:  0.998943387
p_ni:  0.00105649
p_wrong:  1.23e-7
Data Source:  BioPlex
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.99894309
p_ni:  0.00105691
Data Source:  BioPlex
THBS2
Tbio
Novelty:  0.00310724
p_int:  0.985939374
p_ni:  0.014060626
Score:  0.173
Data Source:  BioPlex,STRINGDB
IL27RA
Tbio
Novelty:  0.01348051
p_int:  0.976288618
p_ni:  0.023711382
Data Source:  BioPlex
IFNLR1
Tbio
Novelty:  0.01990628
p_int:  0.968160984
p_ni:  0.031827072
p_wrong:  0.000011944
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Lysosome Vesicle Biogenesis (R-HSA-432720)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lysosome Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Lysosome Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
resting heart rate
1
1
0
7.4
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
resting heart rate
0
7.4
17.8
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 1 subunit gamma 2
VGNC:7433
467407
Macaque
adaptor related protein complex 1 gamma 2 subunit
714237
Mouse
MGI:1328307
11766
Rat
RGD:2324507
100362547
Dog
adaptor related protein complex 1 subunit gamma 2
VGNC:37953
480253
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 1 subunit gamma 2
Macaque
adaptor related protein complex 1 gamma 2 subunit
Mouse
Rat
Dog
adaptor related protein complex 1 subunit gamma 2
Publication Statistics
PubMed Score 7.17
PubMed score by year
PubTator Score 5.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title