Protein Summary
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene ...more
- ENST00000374700
- ENSP00000363832
- ENSG00000138356
- AO
- AO
- AOH1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.96 | ||
disease perturbation | 0.95 | ||
PubMedID | 0.82 | ||
histone modification site profile | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 363.44 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 213 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 363.44 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 213 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 7
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (7)
Active Ligands (2)
Protein-Protein Interactions (136)
Nearest Tclin Targets (9)
Upstream (5)
Downstream (4)
1 – 5 of 5
Pathways (23)
Reactome (4)
KEGG (9)
PathwayCommons (2)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Reactome | Vitamins B6 activation to pyridoxal phosphate | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Vitamins B6 activation to pyridoxal phosphate | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (13)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | aldehyde oxidase 1 | VGNC:10582 | 459863 | |||||
Macaque | aldehyde oxidase 1 | 701024 | ||||||
Mouse | MGI:88035 | 11761 | ||||||
Rat | RGD:620528 | 54349 | ||||||
Horse | aldehyde oxidase 1 | 100070976 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | aldehyde oxidase 1 | |||||
Macaque | aldehyde oxidase 1 | |||||
Mouse | ||||||
Rat | ||||||
Horse | aldehyde oxidase 1 | |||||
Publication Statistics
PubMed Score 363.44
PubMed score by year
PubTator Score 322.89
PubTator score by year
Related Publications
Text Mined References (33)
GeneRif Annotations (17)
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