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Tbio
AOPEP
Aminopeptidase O

Protein Summary
Description
Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart. This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277198
  • ENSP00000277198
  • ENSG00000148120
  • ENST00000297979
  • ENSP00000297979
  • ENST00000375315
  • ENSP00000364464

Symbol
  • C9orf3
  • ONPEP
  • APO
  • AP-O
  • ONPEP
  • C90RF3
  • C9orf3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.16   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.16   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
LRRC40
Tdark
Novelty:  2.43377466
p_int:  0.999928093
p_ni:  0.000071907
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
ZDHHC17
Tbio
Family:  Enzyme
Novelty:  0.03288707
p_int:  0.989136232
p_ni:  0.010858975
p_wrong:  0.000004793
Score:  0.199
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.891428458
p_ni:  0.108571542
Data Source:  BioPlex
SUZ12
Tbio
Novelty:  0.00402353
p_int:  0.796513922
p_ni:  0.203171611
p_wrong:  0.000314467
Score:  0.189
Data Source:  BioPlex,STRINGDB
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.767165823
p_ni:  0.232834177
Data Source:  BioPlex
AGT
Tbio
Novelty:  0.00049613
Score:  0.903
Data Source:  Reactome,STRINGDB
DENND1A
Tbio
Novelty:  0.04823149
Score:  0.674
Data Source:  STRINGDB
SYNPO2L
Tbio
Novelty:  0.21505129
Score:  0.657
Data Source:  STRINGDB
THADA
Tbio
Novelty:  0.06983966
Score:  0.571
Data Source:  STRINGDB
TOX3
Tbio
Family:  TF
Novelty:  0.01573159
Score:  0.56
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of Angiotensinogen to Angiotensins (R-HSA-2022377)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Peptide hormone metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.1
98.4
3
3
1
1.3
92.7
calcium measurement
3
3
4
90.7
appendicular lean mass
1
1
1
61.9
1
1
1
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
98.4
1
1.3
92.7
calcium measurement
4
90.7
appendicular lean mass
1
61.9
1
61.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 83.16
PubMed score by year
PubTator Score 105.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title