Tchem AOC3 Membrane primary amine oxidase

Protein Summary

Description

Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Uniprot Accession IDs

• Q16853
• B2RCI5
• K7ESB3
• L0L8N9
• Q45F94

Gene Name

• AOC3

Ensembl ID

• ENST00000308423
• ENSP00000312326
• ENSG00000131471
• ENST00000591562
• ENSP00000468632
• ENST00000613571
• ENSP00000484312
• ENST00000617500
• ENSP00000477686

Symbol

• VAP1
• HPAO
• SSAO
• VAP1
• VAP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.97
PubMedID	0.86
protein domain	0.85
biological term	0.72
gene perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1078.19   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 384   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1078.19   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 168

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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1 – 1 of 1

phenelzine

AOC3Tchem Enzyme

INHIBITOR pIC50 : 6.84

Active Ligands (168)

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1 – 10 of 168

mofegiline

AOC3Tchem Enzyme

pKi : 7.55

CHEMBL2029537

AOC3Tchem Enzyme

pIC50 : 8

CHEMBL2029533

AOC3Tchem Enzyme

pIC50 : 7.52

CHEMBL2029540

AOC3Tchem Enzyme

pIC50 : 7.52

CHEMBL2029536

AOC3Tchem Enzyme

pIC50 : 7.16

CHEMBL2029538

AOC3Tchem Enzyme

pIC50 : 7.05

CHEMBL2029539

AOC3Tchem Enzyme

pIC50 : 7.4

CHEMBL2029534

AOC3Tchem Enzyme

pIC50 : 7.7

(E)-3-fluoro-4-phenoxybut-2-en-1-amine

AOC3Tchem Enzyme

pIC50 : 6.75

CHEMBL2029531

AOC3Tchem Enzyme

pIC50 : 6.8

Protein-Protein Interactions (63)

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1 – 10 of 63

• See Interactions on String-DB

AOC2

Tchem

Family:  Enzyme

Novelty:  0.0048282

p_int:  0.99999999

p_wrong:  9e-9

Score:  0.867

Data Source:  BioPlex,STRINGDB

EXTL2

Tbio

Family:  Enzyme

Novelty:  0.05051027

p_int:  0.999303611

p_ni:  0.000672676

p_wrong:  0.000023714

Score:  0.189

Data Source:  BioPlex,STRINGDB

SLC9A1

Tchem

Family:  Transporter

Novelty:  0.00096678

p_int:  0.998846028

p_ni:  0.001153964

p_wrong:  9e-9

Score:  0.216

Data Source:  BioPlex,STRINGDB

MANEA

Tbio

Family:  Enzyme

Novelty:  0.03693244

p_int:  0.997717642

p_ni:  0.002282354

p_wrong:  4e-9

Score:  0.189

Data Source:  BioPlex,STRINGDB

ERF

Tbio

Family:  TF

Novelty:  0.00182385

p_int:  0.944216636

p_ni:  0.052400512

p_wrong:  0.003382852

Score:  0.215

Data Source:  BioPlex,STRINGDB

ARL6IP6

Tdark

Novelty:  0.36643453

p_int:  0.8492064

p_ni:  0.150793596

p_wrong:  3e-9

Score:  0.188

Data Source:  BioPlex,STRINGDB

MAOA

Tclin

Family:  Enzyme

Novelty:  0.00031037

Score:  0.943

Data Source:  STRINGDB

MAOB

Tclin

Family:  Enzyme

Novelty:  0.00030366

Score:  0.943

Data Source:  STRINGDB

ALDH2

Tclin

Family:  Enzyme

Novelty:  0.00077122

Score:  0.942

Data Source:  STRINGDB

SMOX

Tbio

Family:  Enzyme

Novelty:  0.0071711

Score:  0.936

Data Source:  STRINGDB

Nearest Tclin Targets (3)

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Upstream (2)

Downstream (1)

1 – 2 of 2

DDC

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  3

1: Phenylalanine metabolism

2: Metabolic pathways

3: Tyrosine metabolism

COMT

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Metabolic pathways

2: Tyrosine metabolism

Pathways (27)

Reactome (3)

KEGG (5)

PathwayCommons (9)

WikiPathways (10)

Biological oxidations (R-HSA-211859)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Biological oxidations	221 targets	R-HSA-211859
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Phase I - Functionalization of compounds	105 targets	R-HSA-211945

Name	Explore in Pharos	Explore in Source
Biological oxidations	221 targets	R-HSA-211859
Metabolism	2112 targets	R-HSA-1430728
Phase I - Functionalization of compounds	105 targets	R-HSA-211945

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (10)

Components (8)

Processes (6)

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1 – 10 of 10

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
copper ion binding	Inferred from Direct Assay (IDA)	UniProtKB
primary amine oxidase activity	Inferred from Direct Assay (IDA)	UniProtKB
quinone binding	Inferred from Direct Assay (IDA)	UniProtKB
protein heterodimerization activity	Inferred from Physical Interaction (IPI)	UniProtKB
protein homodimerization activity	Traceable Author Statement (TAS)	UniProtKB
aliphatic-amine oxidase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
aminoacetone:oxygen oxidoreductase(deaminating) activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
phenethylamine:oxygen oxidoreductase (deaminating) activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
tryptamine:oxygen oxidoreductase (deaminating) activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations (null)

No disease associations found

GWAS Traits (9)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	2	3	3		72.9
waist-hip ratio	EFO_0004343	1	2	2		62
triglyceride measurement	EFO_0004530	1	1	1		33.1
type II diabetes mellitus	EFO_0001360	2	1	1	1.1	26.1
pulse pressure measurement	EFO_0005763	1	1	1		21.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	3		72.9
waist-hip ratio	EFO_0004343	2		62
triglyceride measurement	EFO_0004530	1		33.1
type II diabetes mellitus	EFO_0001360	1	1.1	26.1
pulse pressure measurement	EFO_0005763	1		21.3

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Complete proteome
Copper
Direct protein sequencing
Disulfide bond
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist-hip ratio
body mass index
lymphocyte percentage of leukocytes
neutrophil percentage of leukocytes
pulse pressure measurement
triglyceride measurement
type II diabetes mellitus
waist circumference
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	amine oxidase, copper containing 3	VGNC:6339	454702
Macaque	amine oxidase, copper containing 3		711820
Mouse	amine oxidase, copper containing 3	MGI:1306797	11754
Dog	amine oxidase, copper containing 3	VGNC:37949	480511
Horse	membrane primary amine oxidase		100065767

Species	Name	OMA	EggNOG	Inparanoid
Chimp	amine oxidase, copper containing 3
Macaque	amine oxidase, copper containing 3
Mouse	amine oxidase, copper containing 3
Dog	amine oxidase, copper containing 3
Horse	membrane primary amine oxidase

Publication Statistics

PubMed Score 1078.19

PubMed score by year

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PubTator Score 184.62

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Related Publications

Text Mined References (87)

GeneRif Annotations (72)

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PMID	Year	Title