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Tchem
AOC2
Retina-specific copper amine oxidase

Protein Summary
Description
Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253799
  • ENSP00000253799
  • ENSG00000131480
  • ENST00000452774
  • ENSP00000406134

Symbol
  • RAO
  • DAO2
  • SSAO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.67
tissue sample
0.66
pathway
0.53
cell line
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.49   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.49   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (53)
AOC3
Tchem
Family:  Enzyme
Novelty:  0.00078739
p_int:  0.99999999
p_wrong:  9e-9
Score:  0.867
Data Source:  BioPlex,STRINGDB
LEMD3
Tbio
Novelty:  0.00579701
p_int:  0.997592199
p_ni:  0.002407801
Score:  0.187
Data Source:  BioPlex,STRINGDB
GOLGA5
Tbio
Novelty:  0.04940885
p_int:  0.87663693
p_ni:  0.12336307
Score:  0.189
Data Source:  BioPlex,STRINGDB
MAOB
Tclin
Family:  Enzyme
Novelty:  0.00030366
Score:  0.948
Data Source:  STRINGDB
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
Score:  0.948
Data Source:  STRINGDB
SMOX
Tchem
Family:  Enzyme
Novelty:  0.0071711
Score:  0.943
Data Source:  STRINGDB
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
Score:  0.939
Data Source:  STRINGDB
ALDH1A3
Tchem
Family:  Enzyme
Novelty:  0.00691116
Score:  0.922
Data Source:  STRINGDB
ALDH3B1
Tbio
Family:  Enzyme
Novelty:  0.03330389
Score:  0.916
Data Source:  STRINGDB
ALDH3A1
Tchem
Family:  Enzyme
Novelty:  0.00592398
Score:  0.915
Data Source:  STRINGDB
Pathways (17)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
4
6
79.6
type 2 diabetes mellitus
2
1
1
1.1
39.6
pulse pressure measurement
1
1
1
31.9
body mass index
2
2
2
23.7
triglyceride measurement
1
1
1
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
79.6
type 2 diabetes mellitus
1
1.1
39.6
pulse pressure measurement
1
31.9
body mass index
2
23.7
triglyceride measurement
1
22.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amine oxidase, copper containing 2
VGNC:6338
107969160
Macaque
amine oxidase, copper containing 2
100431015
Mouse
MGI:2668431
237940
Dog
amine oxidase, copper containing 2
VGNC:37948
490957
Horse
amine oxidase, copper containing 2
VGNC:15370
100630218
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amine oxidase, copper containing 2
Macaque
amine oxidase, copper containing 2
Mouse
Dog
amine oxidase, copper containing 2
Horse
amine oxidase, copper containing 2
Publication Statistics
PubMed Score 255.49
PubMed score by year
PubTator Score 149.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title