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Tbio
ANXA11
Annexin A11

Protein Summary
Description
Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265447
  • ENSP00000265447
  • ENSG00000122359
  • ENST00000372231
  • ENSP00000361305
  • ENST00000422982
  • ENSP00000404412
  • ENST00000438331
  • ENSP00000398610

Symbol
  • ANX11
  • ALS23
  • ANX11
  • CAP50
  • CAP-50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
interacting protein
0.98
kinase perturbation
0.95
transcription factor binding site profile
0.88
molecular function
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.63   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.63   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
CST6
Tbio
Novelty:  0.02811473
p_int:  0.888113889
p_ni:  0.110844958
p_wrong:  0.001041153
Score:  0.346
Data Source:  BioPlex,STRINGDB
ANXA2
Tbio
Novelty:  0.00103362
Score:  0.877
Data Source:  STRINGDB
STXBP2
Tbio
Novelty:  0.01896992
Score:  0.872
Data Source:  STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
Score:  0.865
Data Source:  STRINGDB
S100A6
Tbio
Novelty:  0.00176164
Score:  0.837
Data Source:  STRINGDB
ANXA3
Tbio
Novelty:  0.00615077
Score:  0.824
Data Source:  STRINGDB
DYSF
Tbio
Novelty:  0.00248634
Score:  0.75
Data Source:  STRINGDB
PLAC9
Tdark
Novelty:  0.23764669
Score:  0.743
Data Source:  STRINGDB
PDCD6
Tbio
Novelty:  0.0139857
Score:  0.74
Data Source:  STRINGDB
EWSR1
Tbio
Novelty:  0.00068411
Score:  0.723
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
2
3
57.1
serum urea measurement
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
57.1
serum urea measurement
1
37.6
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
annexin A11
707628
Mouse
MGI:108481
11744
Rat
RGD:1309911
290527
Dog
annexin A11
VGNC:37938
479259
Horse
annexin A11
VGNC:15360
100064425
Species
Name
OMA
EggNOG
Inparanoid
Macaque
annexin A11
Mouse
Rat
Dog
annexin A11
Horse
annexin A11
Publication Statistics
PubMed Score 113.63
PubMed score by year
PubTator Score 44.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title