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Tbio
ANTXR1
Anthrax toxin receptor 1

Protein Summary
Description
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode diffe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303714
  • ENSP00000301945
  • ENSG00000169604
  • ENST00000409349
  • ENSP00000386494
  • ENST00000409829
  • ENSP00000387058

Symbol
  • ATR
  • TEM8
  • ATR
  • GAPO
  • TEM8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
transcription factor perturbation
0.88
PubMedID
0.84
ligand (protein) perturbation
0.83
kinase perturbation
0.81


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.57   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 569   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.57   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 569   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
H6PD
Tbio
Novelty:  0.00366637
p_int:  0.99996046
p_ni:  0.000039515
p_wrong:  2.5e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
DNAJC12
Tbio
Novelty:  0.05214775
p_int:  0.999622161
p_ni:  0.000377838
Data Source:  BioPlex
PDIA5
Tbio
Family:  Enzyme
Novelty:  0.06234465
p_int:  0.999171098
p_ni:  0.000828902
Data Source:  BioPlex
CA11
Tchem
Family:  Enzyme
Novelty:  0.15953226
p_int:  0.995536308
p_ni:  0.001188929
p_wrong:  0.003274763
Score:  0.169
Data Source:  BioPlex,STRINGDB
LMO1
Tbio
Novelty:  0.01670419
p_int:  0.989414643
p_ni:  0.010585354
p_wrong:  3e-9
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.986984607
p_ni:  0.013015393
Data Source:  BioPlex
PRMT2
Tbio
Family:  Epigenetic
Novelty:  0.04121581
p_int:  0.981454101
p_ni:  0.018545899
Data Source:  BioPlex
OBSL1
Tbio
Novelty:  0.0325947
p_int:  0.97826208
p_ni:  0.02173792
Score:  0.204
Data Source:  BioPlex,STRINGDB
B4GALNT4
Tdark
Family:  Enzyme
Novelty:  0.19278471
p_int:  0.963665579
p_ni:  0.00004201
p_wrong:  0.036292412
Score:  0.218
Data Source:  BioPlex,STRINGDB
FOXF2
Tbio
Family:  TF
Novelty:  0.02032168
p_int:  0.962575157
p_ni:  0.005368799
p_wrong:  0.032056044
Score:  0.224
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
Uptake and actions of bacterial toxins
Reactome
Uptake and function of anthrax toxins
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
Uptake and actions of bacterial toxins
Uptake and function of anthrax toxins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
3
6
83.3
body height
2
3
3
58.3
BMI-adjusted hip circumference
1
2
2
57.6
1
1
0
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
6
83.3
body height
3
58.3
BMI-adjusted hip circumference
2
57.6
0
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anthrax toxin receptor 1
VGNC:16
470393
Macaque
anthrax toxin receptor 1
100425392
Mouse
MGI:1916788
69538
Rat
RGD:1307144
362393
Dog
ANTXR cell adhesion molecule 1
VGNC:37935
612601
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anthrax toxin receptor 1
Macaque
anthrax toxin receptor 1
Mouse
Rat
Dog
ANTXR cell adhesion molecule 1
Publication Statistics
PubMed Score 223.57
PubMed score by year
PubTator Score 56.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title