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Tchem
ANPEP
Aminopeptidase N

Protein Summary
Description
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300060
  • ENSP00000300060
  • ENSG00000166825

Symbol
  • APN
  • CD13
  • PEPN
  • APN
  • CD13
  • LAP1
  • P150
  • PEPN
  • GP150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
biological term
0.8
kinase perturbation
0.76
disease
0.75
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2525.48   (req: < 5)
Gene RIFs: 93   (req: <= 3)
Antibodies: 1730   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2525.48   (req: >= 5)
Gene RIFs: 93   (req: > 3)
Antibodies: 1730   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 163
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1