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Tchem
ANPEP
Aminopeptidase N

Protein Summary
Description
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300060
  • ENSP00000300060
  • ENSG00000166825

Symbol
  • APN
  • CD13
  • PEPN
  • APN
  • CD13
  • LAP1
  • P150
  • PEPN
  • GP150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
biological term
0.8
kinase perturbation
0.76
disease
0.75
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2329.19   (req: < 5)
Gene RIFs: 93   (req: <= 3)
Antibodies: 1730   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2329.19   (req: >= 5)
Gene RIFs: 93   (req: > 3)
Antibodies: 1730   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 158
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (158)
compound 1a [PMID: 25692029]
Rendered image for compound 1a [PMID: 25692029]
CHEMBL3355101
Rendered image for CHEMBL3355101
Tosedostat
Rendered image for Tosedostat
CHEMBL3355104
Rendered image for CHEMBL3355104
CHEMBL327844
Rendered image for CHEMBL327844
CHEMBL88808
Rendered image for CHEMBL88808
CHEMBL1782887
Rendered image for CHEMBL1782887
CHEMBL3244800
Rendered image for CHEMBL3244800
CHEMBL3355106
Rendered image for CHEMBL3355106
Protein-Protein Interactions (173)
GGT6
Tbio
Family:  Enzyme
Novelty:  0.016069
Score:  0.952
Data Source:  STRINGDB
GGT7
Tbio
Family:  Enzyme
Novelty:  0.01374716
Score:  0.948
Data Source:  STRINGDB
ITGA6
Tbio
Novelty:  0.00217985
Score:  0.944
Data Source:  STRINGDB
GGT5
Tbio
Family:  Enzyme
Novelty:  0.00602505
Score:  0.944
Data Source:  STRINGDB
LAP3
Tchem
Family:  Enzyme
Novelty:  0.00327467
Score:  0.939
Data Source:  STRINGDB
GCLC
Tchem
Family:  Enzyme
Novelty:  0.00217206
Score:  0.938
Data Source:  STRINGDB
GGT1
Tbio
Family:  Enzyme
Novelty:  0.00252374
Score:  0.937
Data Source:  STRINGDB
NAT8
Tbio
Family:  Enzyme
Novelty:  0.02178437
Score:  0.929
Data Source:  STRINGDB
CD33
Tclin
Novelty:  0.00074958
Score:  0.922
Data Source:  STRINGDB
AGT
Tbio
Novelty:  0.00049613
Score:  0.922
Data Source:  Reactome,STRINGDB
Pathways (15)
Immune System (R-HSA-168256)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
8
4
1.1
97.1
serum alanine aminotransferase measurement
2
2
1
6.3
86.3
intraocular pressure measurement
1
2
2
69.6
blood metabolite measurement
1
1
1
54.4
aspartate aminotransferase measurement
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
97.1
serum alanine aminotransferase measurement
1
6.3
86.3
intraocular pressure measurement
2
69.6
blood metabolite measurement
1
54.4
aspartate aminotransferase measurement
1
53.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alanyl aminopeptidase, membrane
107968418
Macaque
alanyl aminopeptidase, membrane
701117
Mouse
MGI:5000466
16790
Rat
RGD:2991
81641
Dog
alanyl aminopeptidase, membrane
VGNC:53146
403913
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alanyl aminopeptidase, membrane
Macaque
alanyl aminopeptidase, membrane
Mouse
Rat
Dog
alanyl aminopeptidase, membrane
Publication Statistics
PubMed Score 2329.19
PubMed score by year
PubTator Score 1378.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title