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Tbio
ANP32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

Protein Summary
Description
Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000465139
  • ENSP00000417864
  • ENSG00000140350

Symbol
  • C15orf1
  • LANP
  • MAPM
  • PHAP1
  • LANP
  • MAPM
  • PP32
  • HPPCn
  • PHAP1
  • PHAPI
  • I1PP2A
  • C15orf1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.97
transcription factor binding site profile
0.86
co-expressed gene
0.72
microRNA
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.9   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 452   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.9   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
SET
Tbio
Novelty:  0.01012327
Score:  0.99
Data Source:  STRINGDB
ELAVL1
Tchem
Novelty:  0.00110045
Score:  0.988
Data Source:  STRINGDB
XPO1
Tclin
Novelty:  0.00078187
Score:  0.982
Data Source:  STRINGDB
APEX1
Tchem
Family:  Enzyme
Novelty:  0.00037532
Score:  0.981
Data Source:  STRINGDB
GZMA
Tbio
Family:  Enzyme
Novelty:  0.00322362
Score:  0.974
Data Source:  STRINGDB
NME1
Tbio
Family:  Kinase
Novelty:  0.00103216
Score:  0.973
Data Source:  STRINGDB
HMGB2
Tbio
Family:  TF
Novelty:  0.01761676
Score:  0.955
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.942
Data Source:  STRINGDB
ANP32E
Tbio
Novelty:  0.06885748
Score:  0.924
Data Source:  STRINGDB
NUP214
Tbio
Novelty:  0.00924336
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
HuR (ELAVL1) binds and stabilizes mRNA (R-HSA-450520)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HuR (ELAVL1) binds and stabilizes mRNA
Reactome
Metabolism of RNA
Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements
Name
Explore in Pharos
Explore in Source
HuR (ELAVL1) binds and stabilizes mRNA
Metabolism of RNA
Regulation of mRNA stability by proteins that bind AU-rich elements
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
28.6
Agents acting on the renin-angiotensin system use measurement
1
1
1
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
28.6
Agents acting on the renin-angiotensin system use measurement
1
3
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acidic nuclear phosphoprotein 32 family member A
748502
Macaque
acidic nuclear phosphoprotein 32 family member A
694356
Mouse
MGI:108447
11737
Rat
RGD:2116
25379
Dog
acidic nuclear phosphoprotein 32 family member A
403534
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acidic nuclear phosphoprotein 32 family member A
Macaque
acidic nuclear phosphoprotein 32 family member A
Mouse
Rat
Dog
acidic nuclear phosphoprotein 32 family member A
Publication Statistics
PubMed Score 215.90
PubMed score by year
PubTator Score 83.77
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title