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Tbio
ANO7
Anoctamin-7

Protein Summary
Description
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions. This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274979
  • ENSP00000274979
  • ENSG00000146205
  • ENST00000402430
  • ENSP00000385418
  • ENST00000402530
  • ENSP00000383985

Symbol
  • NGEP
  • PCANAP5
  • TMEM16G
  • NGEP
  • DTMPP
  • IPCA5
  • D-TMPP
  • IPCA-5
  • PCANAP5
  • TMEM16G
  • PCANAP5L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
tissue sample
0.68
cell line
0.67
cellular component
0.67
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.07   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.07   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
ACPP
Tchem
Family:  Enzyme
Novelty:  0.00364265
Score:  0.712
Data Source:  STRINGDB
THAP4
Tbio
Family:  TF
Novelty:  0.19820029
Score:  0.643
Data Source:  STRINGDB
KLK2
Tchem
Family:  Enzyme
Novelty:  0.00511717
Score:  0.642
Data Source:  STRINGDB
KLKB1
Tclin
Family:  Enzyme
Novelty:  0.00109438
Score:  0.641
Data Source:  STRINGDB
C2orf54
Tdark
Novelty:  1.82354708
Score:  0.631
Data Source:  STRINGDB
ANKMY1
Tbio
Novelty:  0.15068511
Score:  0.629
Data Source:  STRINGDB
PLSCR5
Tdark
Family:  Enzyme
Novelty:  1.58520094
Score:  0.546
Data Source:  STRINGDB
THAP8
Tdark
Family:  TF
Novelty:  3.10152067
Score:  0.533
Data Source:  STRINGDB
GBA
Tclin
Family:  Enzyme
Novelty:  0.00051172
Score:  0.522
Data Source:  STRINGDB
KLK3
Tclin
Family:  Enzyme
Novelty:  0.00003606
Score:  0.52
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
92.5
fibrinogen measurement
2
1
2
84.3
alkaline phosphatase measurement
2
2
1
6.3
79.6
balding measurement
1
1
1
71
mean corpuscular volume
1
1
1
63.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
92.5
fibrinogen measurement
2
84.3
alkaline phosphatase measurement
1
6.3
79.6
balding measurement
1
71
mean corpuscular volume
1
63.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anoctamin 7
VGNC:72
743987
Macaque
anoctamin 7
700819
Mouse
MGI:3052714
404545
Rat
RGD:1302987
367318
Dog
anoctamin 7
486204
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anoctamin 7
Macaque
anoctamin 7
Mouse
Rat
Dog
anoctamin 7
Publication Statistics
PubMed Score 24.07
PubMed score by year
PubTator Score 12.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title