You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ANKS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Protein Summary
Description
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341752
  • ENSP00000345510
  • ENSG00000185046
  • ENST00000546568
  • ENSP00000448205
  • ENST00000546960
  • ENSP00000447839
  • ENST00000547010
  • ENSP00000448512
  • ENST00000547446
  • ENSP00000450015
  • ENST00000547776
  • ENSP00000449629
  • ENST00000549025
  • ENSP00000447312
  • ENST00000549493
  • ENSP00000448203
  • ENST00000549558
  • ENSP00000448993
  • ENST00000550693
  • ENSP00000447999

Symbol
  • EB1
  • AIDA
  • EB-1
  • ANKS2
  • AIDA-1
  • cajalin-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.92
histone modification site profile
0.78
cellular component
0.73
transcription factor
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.93   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.93   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
CASS4
Tbio
Novelty:  0.01000437
Score:  0.766
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.682
Data Source:  STRINGDB
ZNF76
Tbio
Family:  TF
Novelty:  0.22129218
Score:  0.576
Data Source:  STRINGDB
CNTNAP5
Tbio
Novelty:  0.09102959
Score:  0.569
Data Source:  STRINGDB
PHACTR1
Tbio
Family:  Enzyme
Novelty:  0.00901547
Score:  0.549
Data Source:  STRINGDB
UHRF1BP1
Tbio
Novelty:  0.1588079
Score:  0.543
Data Source:  STRINGDB
TAF11
Tchem
Novelty:  0.10299251
Score:  0.527
Data Source:  STRINGDB
ANKRD46
Tbio
Novelty:  0.06546845
Score:  0.521
Data Source:  STRINGDB
SNRPC
Tbio
Novelty:  0.02049921
Score:  0.51
Data Source:  STRINGDB
DLG2
Tbio
Novelty:  0.00999909
Score:  0.506
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Find Similar Targets
Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Mammary gland development pathway - Puberty (Stage 2 of 4)
WikiPathways
MAPK Signaling Pathway
WikiPathways
Prolactin Signaling Pathway
Name
Explore in Pharos
Explore in Source
Ectoderm Differentiation
Ectoderm Differentiation
Mammary gland development pathway - Puberty (Stage 2 of 4)
MAPK Signaling Pathway
Prolactin Signaling Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
4
4
88.5
sex hormone-binding globulin measurement
6
1
6
79.3
methamphetamine dependence
1
1
1
57.7
1
1
1
57.7
alcohol dependence
1
1
1
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
88.5
sex hormone-binding globulin measurement
6
79.3
methamphetamine dependence
1
57.7
1
57.7
alcohol dependence
1
57.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and sterile alpha motif domain containing 1B
VGNC:4925
739384
Macaque
ankyrin repeat and sterile alpha motif domain-containing protein 1B
694033
Mouse
MGI:1924781
77531
Rat
RGD:1565556
314721
Dog
ankyrin repeat and sterile alpha motif domain containing 1B
VGNC:37917
482621
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and sterile alpha motif domain containing 1B
Macaque
ankyrin repeat and sterile alpha motif domain-containing protein 1B
Mouse
Rat
Dog
ankyrin repeat and sterile alpha motif domain containing 1B
Publication Statistics
PubMed Score 37.93
PubMed score by year
PubTator Score 29.80
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title