ANKS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B
Protein Summary
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
- ENST00000341752
- ENSP00000345510
- ENSG00000185046
- ENST00000546568
- ENSP00000448205
- ENST00000546960
- ENSP00000447839
- ENST00000547010
- ENSP00000448512
- ENST00000547446
- ENSP00000450015
- ENST00000547776
- ENSP00000449629
- ENST00000549025
- ENSP00000447312
- ENST00000549493
- ENSP00000448203
- ENST00000549558
- ENSP00000448993
- ENST00000550693
- ENSP00000447999
- EB1
- AIDA
- EB-1
- ANKS2
- AIDA-1
- cajalin-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
protein domain | 0.92 | ||
histone modification site profile | 0.78 | ||
cellular component | 0.73 | ||
transcription factor | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.93 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 142 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.93 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 142 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0