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Tbio
ANKS1A
Ankyrin repeat and SAM domain-containing protein 1A

Protein Summary
Description
Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360359
  • ENSP00000353518
  • ENSG00000064999

Symbol
  • ANKS1
  • KIAA0229
  • ODIN
  • ANKS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
protein domain
0.92
disease perturbation
0.87
transcription factor binding site profile
0.87
histone modification site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.59   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.59   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
RIN1
Tbio
Novelty:  0.02401084
p_int:  0.999999961
p_ni:  3.7e-8
p_wrong:  1e-9
Score:  0.32
Data Source:  BioPlex,STRINGDB
DAB2IP
Tchem
Novelty:  0.01423445
p_int:  0.999999941
p_ni:  5.7e-8
p_wrong:  1e-9
Score:  0.314
Data Source:  BioPlex,STRINGDB
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.999998814
p_ni:  3.8e-8
p_wrong:  0.000001148
Score:  0.27
Data Source:  BioPlex,STRINGDB
DEF6
Tbio
Novelty:  0.0378487
p_int:  0.999670842
p_ni:  0.000329062
p_wrong:  9.6e-8
Score:  0.288
Data Source:  BioPlex,STRINGDB
RINL
Tbio
Novelty:  0.35318519
Score:  0.777
Data Source:  STRINGDB
EPHA8
Tchem
Family:  Kinase
Novelty:  0.02244256
Score:  0.76
Data Source:  STRINGDB
PHACTR1
Tbio
Family:  Enzyme
Novelty:  0.00901547
Score:  0.715
Data Source:  STRINGDB
BCAS3
Tbio
Novelty:  0.0343539
Score:  0.692
Data Source:  STRINGDB
UHRF1BP1
Tbio
Novelty:  0.1588079
Score:  0.687
Data Source:  STRINGDB
SCUBE3
Tbio
Novelty:  0.08124826
Score:  0.682
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (45)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
5
6
97.3
BMI-adjusted hip circumference
4
17
22
94.4
BMI-adjusted waist circumference
4
7
9
93.3
7
5
0
1.2
91.2
BMI-adjusted waist-hip ratio
3
4
5
90.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
97.3
BMI-adjusted hip circumference
22
94.4
BMI-adjusted waist circumference
9
93.3
0
1.2
91.2
BMI-adjusted waist-hip ratio
5
90.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and sterile alpha motif domain containing 1A
VGNC:2640
462632
Macaque
ankyrin repeat and sterile alpha motif domain containing 1A
677717
Mouse
MGI:2446180
224650
Rat
RGD:1309183
309639
Dog
ankyrin repeat and sterile alpha motif domain containing 1A
VGNC:37916
608187
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and sterile alpha motif domain containing 1A
Macaque
ankyrin repeat and sterile alpha motif domain containing 1A
Mouse
Rat
Dog
ankyrin repeat and sterile alpha motif domain containing 1A
Publication Statistics
PubMed Score 59.59
PubMed score by year
PubTator Score 46.07
PubTator score by year
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Related Publications
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PMID
Year
Title