You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ANKRD54
Ankyrin repeat domain-containing protein 54

Protein Summary
Description
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215941
  • ENSP00000215941
  • ENSG00000100124

Symbol
  • LIAR
  • LIAR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
tissue sample
0.61
transcription factor
0.59
transcription factor binding site profile
0.59
kinase perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.01   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.01   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
CTTN
Tbio
Novelty:  0.0017962
p_int:  0.99999979
p_ni:  2.09e-7
Score:  0.224
Data Source:  BioPlex,STRINGDB
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.999999622
p_ni:  1.08e-7
p_wrong:  2.7e-7
Score:  0.544
Data Source:  BioPlex,STRINGDB
BTK
Tclin
Family:  Kinase
Novelty:  0.00050747
p_int:  0.999970474
p_ni:  7.84e-7
p_wrong:  0.000028742
Score:  0.442
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999660863
p_ni:  0.000014362
p_wrong:  0.000324775
Data Source:  BioPlex
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.999620585
p_ni:  0.000001339
p_wrong:  0.000378076
Score:  0.219
Data Source:  BioPlex,STRINGDB
G0S2
Tbio
Novelty:  0.02273959
p_int:  0.999293397
p_ni:  0.000093959
p_wrong:  0.000612644
Data Source:  BioPlex
LIAS
Tbio
Family:  Enzyme
Novelty:  0.01269062
Score:  0.793
Data Source:  STRINGDB
GPSM1
Tbio
Novelty:  0.03510582
Score:  0.722
Data Source:  STRINGDB
GNPAT
Tchem
Family:  Enzyme
Novelty:  0.01255689
Score:  0.66
Data Source:  STRINGDB
ADORA2B
Tclin
Family:  GPCR
Novelty:  0.00096284
Score:  0.649
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
2
2
72.4
sex hormone-binding globulin measurement
4
2
4
69.8
cup-to-disc ratio measurement
2
2
2
67.9
heel bone mineral density
2
1
2
67.1
intraocular pressure measurement
4
3
5
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
2
72.4
sex hormone-binding globulin measurement
4
69.8
cup-to-disc ratio measurement
2
67.9
heel bone mineral density
2
67.1
intraocular pressure measurement
5
67.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 54 [Source:HGNC Symbol;Acc:HGNC:25185]
Mouse
MGI:2444209
223690
Rat
RGD:1309552
362957
Dog
ankyrin repeat domain 54
VGNC:37910
481261
Horse
ankyrin repeat domain 54 [Source:HGNC Symbol;Acc:HGNC:25185]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 54 [Source:HGNC Symbol;Acc:HGNC:25185]
Mouse
Rat
Dog
ankyrin repeat domain 54
Horse
ankyrin repeat domain 54 [Source:HGNC Symbol;Acc:HGNC:25185]
Publication Statistics
PubMed Score 36.01
PubMed score by year
PubTator Score 23.79
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title