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Tdark
ANKRD50
Ankyrin repeat domain-containing protein 50

Protein Summary
Description
Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000504087
  • ENSP00000425658
  • ENSG00000151458
  • ENST00000515641
  • ENSP00000425355

Symbol
  • KIAA1223
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.88
histone modification site profile
0.68
transcription factor binding site profile
0.68
cell type or tissue
0.66
cell line
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.15   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.15   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
RPL23A
Tbio
Novelty:  0.02951947
p_int:  0.999999984
p_ni:  1.5e-8
p_wrong:  1e-9
Data Source:  BioPlex
ODF3
Tbio
Novelty:  0.08747036
p_int:  0.999999945
p_ni:  5.5e-8
Data Source:  BioPlex
ZNF414
Tdark
Novelty:  1.29024829
p_int:  0.999996481
p_ni:  0.000003024
p_wrong:  4.96e-7
Score:  0.24
Data Source:  BioPlex,STRINGDB
DDX41
Tbio
Family:  Enzyme
Novelty:  0.01658581
p_int:  0.999866694
p_ni:  3.07e-7
p_wrong:  0.000132999
Score:  0.246
Data Source:  BioPlex,STRINGDB
ODAPH
Tbio
Novelty:  0.20386223
p_int:  0.999762236
p_ni:  0.000004671
p_wrong:  0.000233093
Score:  0.175
Data Source:  BioPlex,STRINGDB
ARL13B
Tbio
Family:  Enzyme
Novelty:  0.01481674
p_int:  0.995742485
p_ni:  0.000003469
p_wrong:  0.004254046
Score:  0.374
Data Source:  BioPlex,STRINGDB
ENTR1
Tbio
Novelty:  0.32267064
Score:  0.777
Data Source:  STRINGDB
TMEM33
Tbio
Novelty:  0.15083104
Score:  0.739
Data Source:  STRINGDB
ARL9
Tdark
Family:  Enzyme
Novelty:  0.87210932
Score:  0.735
Data Source:  STRINGDB
SPATA5
Tbio
Family:  Enzyme
Novelty:  0.00416454
Score:  0.68
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
56.3
cardiovascular event measurement
1
1
0
2
2.2
response to darapladib
1
1
0
2
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
56.3
cardiovascular event measurement
0
2
2.2
response to darapladib
0
2
2.2
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 50
VGNC:698
461478
Macaque
ankyrin repeat domain 50
709327
Mouse
MGI:2139777
99696
Rat
RGD:1311665
294988
Dog
ankyrin repeat domain 50
VGNC:37907
483835
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 50
Macaque
ankyrin repeat domain 50
Mouse
Rat
Dog
ankyrin repeat domain 50
Publication Statistics
PubMed Score 1.15
PubMed score by year
PubTator Score 0.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title